Literature DB >> 7954660

Evidence for the production and action of interleukin-10 in pituitary cells.

T K Hughes1, P Cadet, P L Rady, S K Tyring, R Chin, E M Smith.   

Abstract

1. Interleukin-10 (IL-10) has a wide range of activities in the immune system such as modulation of interferon-gamma (IFN-gamma) and antibody production. The neuropeptide hormone corticotropin (ACTH) has similar activities, suggesting that a bidirectional communication mechanism operates between the immune and the neuroendocrine system involving these two substances. 2. Murine pituitary tumor cells (AtT-20) were found to produce up to 3 ng/ml of IL-10. 3. Pituitary cell corticotropin production was enhanced by IL-10 treatment. 4. IL-10 induced the production of ACTH in mouse splenocytes. 5. Authenticity of pituitary-derived IL-10 was shown by the demonstration of identical nucleic acid sequences of reverse-transcribed, polymerase chain reaction amplified fragments of cDNA obtained from murine splenocytes, a murine pituitary tumor cell line, and freshly isolated murine pituitaries.

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Year:  1994        PMID： 7954660     DOI： 10.1007/BF02088589

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  31 in total

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Journal:  Science       Date:  1990-06-08       Impact factor: 47.728

4.  Corticotropin-releasing factor-induced immunosuppression in human and invertebrate immunocytes.

Authors:  E M Smith; T K Hughes; P Cadet; G B Stefano
Journal:  Cell Mol Neurobiol       Date:  1992-10       Impact factor: 5.046

5.  Human lymphocyte production of corticotropin and endorphin-like substances: association with leukocyte interferon.

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Journal:  Proc Natl Acad Sci U S A       Date:  1981-12       Impact factor: 11.205

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Journal:  J Biol Chem       Date:  1988-07-25       Impact factor: 5.157

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Journal:  J Immunol       Date:  1984-01       Impact factor: 5.422

8.  Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones.

Authors:  D F Fiorentino; M W Bond; T R Mosmann
Journal:  J Exp Med       Date:  1989-12-01       Impact factor: 14.307

9.  Interleukin 10: a novel stimulatory factor for mast cells and their progenitors.

Authors:  L Thompson-Snipes; V Dhar; M W Bond; T R Mosmann; K W Moore; D M Rennick
Journal:  J Exp Med       Date:  1991-02-01       Impact factor: 14.307

10.  Macrophage deactivation by interleukin 10.

Authors:  C Bogdan; Y Vodovotz; C Nathan
Journal:  J Exp Med       Date:  1991-12-01       Impact factor: 14.307
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  8 in total

1.  Genes expressed in the mouse pituitary corticotrope AtT-20/D-16v tumor cell line.

Authors:  M R Schiller
Journal:  Pituitary       Date:  2000-11       Impact factor: 4.107

Review 2.  Paracrinicity: the story of 30 years of cellular pituitary crosstalk.

Authors:  C Denef
Journal:  J Neuroendocrinol       Date:  2008-01       Impact factor: 3.627

3.  Cytokine regulation of tryptophan metabolism in the hypothalamic-pituitary-adrenal (HPA) axis: implications for protective and toxic consequences in neuroendocrine regulation.

Authors:  Huolin Tu; Peter L Rady; Terry Juelich; Eric M Smith; Stephen K Tyring; Thomas K Hughes
Journal:  Cell Mol Neurobiol       Date:  2005-06       Impact factor: 5.046

4.  Presence of interleukin-10 transcripts in human pituitary and hypothalamus.

Authors:  P L Rady; E M Smith; P Cadet; M R Opp; S K Tyring; T K Hughes
Journal:  Cell Mol Neurobiol       Date:  1995-04       Impact factor: 5.046

5.  Interleukin-10 regulated gene expression in cells of hypothalamic-pituitary-adrenal axis origin.

Authors:  Huolin Tu; Peter L Rady; Terry Juelich; Stephen K Tyring; Nina Koldzic-Zivanovic; Eric M Smith; Thomas K Hughes
Journal:  Cell Mol Neurobiol       Date:  2007-02-13       Impact factor: 4.231

6.  IL-10 Gene Rs1800871, Rs1800872, and Rs1800896 Polymorphisms and IL-10 Serum Levels Association with Pituitary Adenoma.

Authors:  Migle Palivonaite; Greta Gedvilaite; Brigita Glebauskiene; Loresa Kriauciuniene; Vita Rovite; Rasa Liutkeviciene
Journal:  Biomedicines       Date:  2022-08-08

7.  Interleukin-10: a key cytokine in depression?

Authors:  Susana Roque; Margarida Correia-Neves; Ana Raquel Mesquita; Joana Almeida Palha; Nuno Sousa
Journal:  Cardiovasc Psychiatry Neurol       Date:  2009-08-16

Review 8.  Infection, immunity and the neuroendocrine response.

Authors:  Paolo Borghetti; Roberta Saleri; Eugenio Mocchegiani; Attilio Corradi; Paolo Martelli
Journal:  Vet Immunol Immunopathol       Date:  2009-02-04       Impact factor: 2.046
  8 in total

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