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Literature DB >> 2161559

Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI.

K W Moore¹, P Vieira, D F Fiorentino, M L Trounstine, T A Khan, T R Mosmann.

Abstract

Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis by TH1 helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.

Entities: Gene Species

Mesh：

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Year: 1990 PMID： 2161559 DOI： 10.1126/science.2161559

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

236 in total

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2. A rhesus macaque rhadinovirus related to Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 encodes a functional homologue of interleukin-6.

Authors: J A Kaleeba; E P Bergquam; S W Wong
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Authors: J Stöckl; H Vetr; O Majdic; G Zlabinger; E Kuechler; W Knapp
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4. Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).

Authors: S V Kotenko; S Saccani; L S Izotova; O V Mirochnitchenko; S Pestka
Journal: Proc Natl Acad Sci U S A Date: 2000-02-15 Impact factor: 11.205

5. Identification and initial characterization of the murine gammaherpesvirus 68 gene M3, encoding an abundantly secreted protein.

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10. Molecular characterization and determination of the coding capacity of the genome of equine herpesvirus type 2 between the genome coordinates 0.235 and 0.258 (the EcoRI DNA fragment N; 4.2 kbp).

Authors: H J Rode; J J Bugert; M Handermann; P Schnitzler; R Kehm; W Janssen; H Delius; G Darai
Journal: Virus Genes Date: 1994-09 Impact factor: 2.332

Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI.

1. Differential up-regulation of circulating soluble selectins and endothelial adhesion molecules in Sicilian patients with Boutonneuse fever.

2. A rhesus macaque rhadinovirus related to Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 encodes a functional homologue of interleukin-6.

3. Human major group rhinoviruses downmodulate the accessory function of monocytes by inducing IL-10.

4. Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).

5. Identification and initial characterization of the murine gammaherpesvirus 68 gene M3, encoding an abundantly secreted protein.

Review 6. Herpesvirus homologues of cellular genes.

Review 7. Advances in gene therapy of liver cirrhosis: a review.

Review 8. Cytokine homologs of human gammaherpesviruses.

9. Elevated chemokine responses are maintained in lungs after clearance of viral infection.

10. Molecular characterization and determination of the coding capacity of the genome of equine herpesvirus type 2 between the genome coordinates 0.235 and 0.258 (the EcoRI DNA fragment N; 4.2 kbp).