Literature DB >> 7938017

The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila.

S Zollman1, D Godt, G G Privé, J L Couderc, F A Laski.   

Abstract

The Drosophila bric à brac protein and the transcriptional regulators encoded by tramtrack and Broad-Complex contain a highly conserved domain of approximately 115 amino acids, which we have called the BTB domain. We have identified six additional Drosophila genes that encode this domain. Five of these genes are developmentally regulated, and one of them appears to be functionally related to bric à brac. The BTB domain defines a gene family with an estimated 40 members in Drosophila. This domain is found primarily at the N terminus of zinc finger proteins and is evolutionarily conserved from Drosophila to mammals.

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Year:  1994        PMID： 7938017      PMCID： PMC45093          DOI： 10.1073/pnas.91.22.10717

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

1.  LAZ3, a novel zinc-finger encoding gene, is disrupted by recurring chromosome 3q27 translocations in human lymphomas.

Authors:  J P Kerckaert; C Deweindt; H Tilly; S Quief; G Lecocq; C Bastard
Journal:  Nat Genet       Date:  1993-09       Impact factor: 38.330

2.  kelch encodes a component of intercellular bridges in Drosophila egg chambers.

Authors:  F Xue; L Cooley
Journal:  Cell       Date:  1993-03-12       Impact factor: 41.582

3.  Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma.

Authors:  B H Ye; F Lista; F Lo Coco; D M Knowles; K Offit; R S Chaganti; R Dalla-Favera
Journal:  Science       Date:  1993-10-29       Impact factor: 47.728

4.  Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger proteins.

Authors:  M Numoto; O Niwa; J Kaplan; K K Wong; K Merrell; K Kamiya; K Yanagihara; K Calame
Journal:  Nucleic Acids Res       Date:  1993-08-11       Impact factor: 16.971

5.  polyhomeotic regulatory sequences induce developmental regulator-dependent variegation and targeted P-element insertions in Drosophila.

Authors:  M O Fauvarque; J M Dura
Journal:  Genes Dev       Date:  1993-08       Impact factor: 11.361

6.  Isolation of cDNAs encoding the Drosophila GAGA transcription factor.

Authors:  W C Soeller; C E Oh; T B Kornberg
Journal:  Mol Cell Biol       Date:  1993-12       Impact factor: 4.272

7.  The enhancer of position-effect variegation of Drosophila, E(var)3-93D, codes for a chromatin protein containing a conserved domain common to several transcriptional regulators.

Authors:  R Dorn; V Krauss; G Reuter; H Saumweber
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-01       Impact factor: 11.205

8.  DNA sequence analysis of conserved and unique regions of swinepox virus: identification of genetic elements supporting phenotypic observations including a novel G protein-coupled receptor homologue.

Authors:  R F Massung; V Jayarama; R W Moyer
Journal:  Virology       Date:  1993-12       Impact factor: 3.616

9.  Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.

Authors:  Z Chen; N J Brand; A Chen; S J Chen; J H Tong; Z Y Wang; S Waxman; A Zelent
Journal:  EMBO J       Date:  1993-03       Impact factor: 11.598

10.  Repression of Drosophila pair-rule segmentation genes by ectopic expression of tramtrack.

Authors:  J L Brown; C Wu
Journal:  Development       Date:  1993-01       Impact factor: 6.868
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  139 in total

1.  Fetal Alz-50 clone 1, a novel zinc finger protein, binds a specific DNA sequence and acts as a transcriptional regulator.

Authors:  K L Jordan-Sciutto; J M Dragich; J L Rhodes; R Bowser
Journal:  J Biol Chem       Date:  1999-12-03       Impact factor: 5.157

2.  Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain.

Authors:  M Soltysik-Espanola; R A Rogers; S Jiang; T A Kim; R Gaedigk; R A White; H Avraham; S Avraham
Journal:  Mol Biol Cell       Date:  1999-07       Impact factor: 4.138

3.  The function of the broad-complex during Drosophila melanogaster oogenesis.

Authors:  G Tzolovsky; W M Deng; T Schlitt; M Bownes
Journal:  Genetics       Date:  1999-11       Impact factor: 4.562

4.  The SCAN domain of ZNF174 is a dimer.

Authors:  James R Stone; Jenny L Maki; Stephen C Blacklow; Tucker Collins
Journal:  J Biol Chem       Date:  2001-12-11       Impact factor: 5.157

5.  In-depth mutational analysis of the promyelocytic leukemia zinc finger BTB/POZ domain reveals motifs and residues required for biological and transcriptional functions.

Authors:  A Melnick; K F Ahmad; S Arai; A Polinger; H Ball; K L Borden; G W Carlile; G G Prive; J D Licht
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

6.  Functional studies of the BTB domain in the Drosophila GAGA and Mod(mdg4) proteins.

Authors:  D Read; M J Butte; A F Dernburg; M Frasch; T B Kornberg
Journal:  Nucleic Acids Res       Date:  2000-10-15       Impact factor: 16.971

7.  Interactions between the Su(Hw) and Mod(mdg4) proteins required for gypsy insulator function.

Authors:  D Ghosh; T I Gerasimova; V G Corces
Journal:  EMBO J       Date:  2001-05-15       Impact factor: 11.598

8.  Species-specific differences in the organization of genes encoding kelch-like proteins of orthopoxviruses pathogenic for humans.

Authors:  S N Shchelkunov; A V Totmenin; I V Kolosova; L S Sandakhchiev
Journal:  Dokl Biochem Biophys       Date:  2002 Mar-Apr       Impact factor: 0.788

9.  The gypsy insulator can act as a promoter-specific transcriptional stimulator.

Authors:  W Wei; M D Brennan
Journal:  Mol Cell Biol       Date:  2001-11       Impact factor: 4.272

10.  Genetic and molecular characterization of the caenorhabditis elegans gene, mel-26, a postmeiotic negative regulator of mei-1, a meiotic-specific spindle component.

Authors:  M R Dow; P E Mains
Journal:  Genetics       Date:  1998-09       Impact factor: 4.562
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