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Literature DB >> 8367294

Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger proteins.

M Numoto¹, O Niwa, J Kaplan, K K Wong, K Merrell, K Kamiya, K Yanagihara, K Calame.

Abstract

We have cloned a cDNA encoding a new murine C2H2 zinc finger protein, ZF5. The 51.3 kD protein contains five GL1-Kruppel type zinc fingers at the C-terminus. At its N-terminus, ZF5 has a 41 amino acid region which was found to be homologous to the N-termini of several other zinc finger proteins. This region defines a new motif within zinc finger proteins which we have named the Zinc finger N-terminal (ZiN) domain. ZF5 binds to two sites in the c-myc promoter and to the -50 bp site of the herpes simplex thymidine kinase promoter. ZF5 is a transcriptional repressor and its repression domain is located N-terminal to the zinc finger domains. A single 4 kb ZF5 mRNA is expressed widely.

Entities: Gene Species

Mesh：

Substances：

Year: 1993 PMID： 8367294 PMCID： PMC309887 DOI： 10.1093/nar/21.16.3767

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

60 in total

1. The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family.

Authors: S D Crosby; J J Puetz; K S Simburger; T J Fahrner; J Milbrandt
Journal: Mol Cell Biol Date: 1991-08 Impact factor: 4.272

2. YY1 is an initiator sequence-binding protein that directs and activates transcription in vitro.

Authors: E Seto; Y Shi; T Shenk
Journal: Nature Date: 1991-11-21 Impact factor: 49.962

3. Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein.

Authors: Y Shi; E Seto; L S Chang; T Shenk
Journal: Cell Date: 1991-10-18 Impact factor: 41.582

4. The Drosophila Broad-Complex encodes a family of related proteins containing zinc fingers.

Authors: P R DiBello; D A Withers; C A Bayer; J W Fristrom; G M Guild
Journal: Genetics Date: 1991-10 Impact factor: 4.562

5. Delta, a transcription factor that binds to downstream elements in several polymerase II promoters, is a functionally versatile zinc finger protein.

Authors: N Hariharan; D E Kelley; R P Perry
Journal: Proc Natl Acad Sci U S A Date: 1991-11-01 Impact factor: 11.205

6. Recognition of DNA by Cys2,His2 zinc fingers.

Authors: R E Klevit
Journal: Science Date: 1991-09-20 Impact factor: 47.728

7. A conserved family of nuclear proteins containing structural elements of the finger protein encoded by Krüppel, a Drosophila segmentation gene.

Authors: R Schuh; W Aicher; U Gaul; S Côté; A Preiss; D Maier; E Seifert; U Nauber; C Schröder; R Kemler
Journal: Cell Date: 1986-12-26 Impact factor: 41.582

8. Functional significance of an overlapping consensus binding motif for Sp1 and Zif268 in the murine adenosine deaminase gene promoter.

Authors: S L Ackerman; A G Minden; G T Williams; C Bobonis; C Y Yeung
Journal: Proc Natl Acad Sci U S A Date: 1991-09-01 Impact factor: 11.205

9. Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site.

Authors: K Park; M L Atchison
Journal: Proc Natl Acad Sci U S A Date: 1991-11-01 Impact factor: 11.205

10. Cloning of a negative transcription factor that binds to the upstream conserved region of Moloney murine leukemia virus.

Authors: J R Flanagan; K G Becker; D L Ennist; S L Gleason; P H Driggers; B Z Levi; E Appella; K Ozato
Journal: Mol Cell Biol Date: 1992-01 Impact factor: 4.272

42 in total

1. BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor.

Authors: C C Chang; B H Ye; R S Chaganti; R Dalla-Favera
Journal: Proc Natl Acad Sci U S A Date: 1996-07-09 Impact factor: 11.205

2. Mutational analysis of the herpes simplex virus type 1 ICP0 C3HC4 zinc ring finger reveals a requirement for ICP0 in the expression of the essential alpha27 gene.

Authors: E K Lium; S Silverstein
Journal: J Virol Date: 1997-11 Impact factor: 5.103

Review 3. Perspectives on zinc finger protein function and evolution--an update.

Authors: T Pieler; E Bellefroid
Journal: Mol Biol Rep Date: 1994-07 Impact factor: 2.316

4. Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site.

Authors: T Oyake; K Itoh; H Motohashi; N Hayashi; H Hoshino; M Nishizawa; M Yamamoto; K Igarashi
Journal: Mol Cell Biol Date: 1996-11 Impact factor: 4.272

5. Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B.

Authors: S Deltour; C Guerardel; D Leprince
Journal: Proc Natl Acad Sci U S A Date: 1999-12-21 Impact factor: 11.205