Literature DB >> 7925852

Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp.

P A Horton1, R E Longley, O J McConnell, L M Ballas.   

Abstract

Staurosporine aglycone (K252-c) (compound 1) and arcyriaflavin A (2) were isolated from a specimen of the marine ascidian, Eudistoma sp., collected off the coast of West Africa. In addition to expressing micromolar and submicromolar inhibition of enzyme activity against seven protein kinase C isoenzymes and inhibition of proliferation of the human lung cancer A549 and P388 murine leukemia cell lines, 1 also inhibited cell adhesion of the EL-4.IL-2 cell line and expressed activity in the K562 bleb and neutrophil assays.

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Year:  1994        PMID： 7925852     DOI： 10.1007/bf01956468

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  12 in total

1.  A derivative of staurosporine (CGP 41 251) shows selectivity for protein kinase C inhibition and in vitro anti-proliferative as well as in vivo anti-tumor activity.

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Journal:  Int J Cancer       Date:  1989-05-15       Impact factor: 7.396

2.  The structures of the novel protein kinase C inhibitors K-252a, b, c and d.

Authors:  T Yasuzawa; T Iida; M Yoshida; N Hirayama; M Takahashi; K Shirahata; H Sano
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3.  K-252b, c and d, potent inhibitors of protein kinase C from microbial origin.

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4.  Lucigenin chemiluminescence in the assessment of neutrophil superoxide production.

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Authors:  G Knübel; L K Larsen; R E Moore; I A Levine; G M Patterson
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6.  Sequence and expression of human protein kinase C-epsilon.

Authors:  P Basta; M B Strickland; W Holmes; C R Loomis; L M Ballas; D J Burns
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7.  Inhibition of multidrug resistance by a new staurosporine derivative, NA-382, in vitro and in vivo.

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8.  Evaluation of marine sponge metabolites for cytotoxicity and signal transduction activity.

Authors:  R E Longley; O J McConnell; E Essich; D Harmody
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Review 9.  The origins of human cancer: molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment--twenty-seventh G.H.A. Clowes memorial award lecture.

Authors:  I B Weinstein
Journal:  Cancer Res       Date:  1988-08-01       Impact factor: 12.701

10.  Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester-induced differentiation of human promyelocytic leukemia cells HL-60.

Authors:  A S Kraft; J B Smith; R L Berkow
Journal:  Proc Natl Acad Sci U S A       Date:  1986-03       Impact factor: 11.205
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4.  Neuronal differentiation by analogs of staurosporine.

Authors:  Alex F Thompson; Leonard A Levin
Journal:  Neurochem Int       Date:  2010-01-04       Impact factor: 3.921

5.  Structure elucidation and anticancer activity of 7-oxostaurosporine derivatives from the Brazilian endemic tunicate Eudistoma vannamei.

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Review 7.  Marine Natural Product Inhibitors of Neutrophil-Associated Inflammation.

Authors:  Chun-Yu Chen; Yung-Fong Tsai; Wen-Yi Chang; Shun-Chin Yang; Tsong-Long Hwang
Journal:  Mar Drugs       Date:  2016-07-26       Impact factor: 5.118

Review 8.  Natural Products Diversity of Marine Ascidians (Tunicates; Ascidiacea) and Successful Drugs in Clinical Development.

Authors:  Satheesh Kumar Palanisamy; N M Rajendran; Angela Marino
Journal:  Nat Prod Bioprospect       Date:  2017-01-17

9.  A Co-Culturing Approach Enables Discovery and Biosynthesis of a Bioactive Indole Alkaloid Metabolite.

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  9 in total

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