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Literature DB >> 2175302

Cytotoxic, antiviral indolocarbazoles from a blue-green alga belonging to the Nostocaceae.

G Knübel¹, L K Larsen, R E Moore, I A Levine, G M Patterson.

Abstract

6-Cyano-5-methoxy-12-methylindolo[2,3-alpha]carbazole and 6-cyano-5-methoxyindolo[2,3-alpha]carbazole are responsible for most of the cytotoxicity and antiviral activity associated with the blue-green alga Nostoc sphaericum EX-5-1. The compounds are active against HSV II and show weak cytotoxicity against KB and LoVo human carcinoma cell lines.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1990 PMID： 2175302 DOI： 10.7164/antibiotics.43.1236

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

8 in total

Review 1. Chemodiversity in freshwater and terrestrial cyanobacteria - a source for drug discovery.

Authors: George E Chlipala; Shunyan Mo; Jimmy Orjala
Journal: Curr Drug Targets Date: 2011-10 Impact factor: 3.465

2. In vitro and in vivo safety assessment of edible blue-green algae, Nostoc commune var. sphaeroides Kützing and Spirulina plantensis.

Authors: Yue Yang; Youngki Park; David A Cassada; Daniel D Snow; Douglas G Rogers; Jiyoung Lee
Journal: Food Chem Toxicol Date: 2011-04-05 Impact factor: 6.023

3. Effects of Long-Term Supplementation of Blue-Green Algae on Lipid Metabolism in C57BL/6J mice.

Authors: Yue Yang; Bohkyung Kim; Young-Ki Park; Ji-Young Lee
Journal: J Nutrit Health Food Sci Date: 2014

4. Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents.

Authors: Songpo Guo; Suresh K Tipparaju; Scott D Pegan; Baojie Wan; Shunyan Mo; Jimmy Orjala; Andrew D Mesecar; Scott G Franzblau; Alan P Kozikowski
Journal: Bioorg Med Chem Date: 2009-09-04 Impact factor: 3.641

Cytotoxic, antiviral indolocarbazoles from a blue-green alga belonging to the Nostocaceae.

Review 1. Chemodiversity in freshwater and terrestrial cyanobacteria - a source for drug discovery.

2. In vitro and in vivo safety assessment of edible blue-green algae, Nostoc commune var. sphaeroides Kützing and Spirulina plantensis.

3. Effects of Long-Term Supplementation of Blue-Green Algae on Lipid Metabolism in C57BL/6J mice.

4. Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents.

5. Hypocholesterolemic effect of Nostoc commune var. sphaeroides Kützing, an edible blue-green alga.

6. Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp.

7. Screening of Norharmane from Seven Cyanobacteria by High-performance Liquid Chromatography.

8. Immunomodulatory Potential of the Polysaccharide-Rich Extract from Edible Cyanobacterium Nostoc commune.