Literature DB >> 3759659

The structures of the novel protein kinase C inhibitors K-252a, b, c and d.

T Yasuzawa, T Iida, M Yoshida, N Hirayama, M Takahashi, K Shirahata, H Sano.   

Abstract

The structures of four new protein kinase C inhibitors of microbial origin, K-252a, b, c and d were determined by spectral studies and chemical conversion.

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Substances：

Year:  1986        PMID： 3759659     DOI： 10.7164/antibiotics.39.1072

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  15 in total

1.  Identification of indolepyruvic acid as an intermediate of rebeccamycin biosynthesis.

Authors:  K S Lam; S Forenza; T W Doyle; C J Pearce
Journal:  J Ind Microbiol       Date:  1990-12

2.  Targeted metagenomics: finding rare tryptophan dimer natural products in the environment.

Authors:  Fang-Yuan Chang; Melinda A Ternei; Paula Y Calle; Sean F Brady
Journal:  J Am Chem Soc       Date:  2015-05-04       Impact factor: 15.419

3.  Synthesis of unsymmetrical 3,4-diaryl-3-pyrrolin-2-ones utilizing pyrrole Weinreb amides.

Authors:  Jessica G Greger; Sarah J P Yoon-Miller; Nathan R Bechtold; Scott A Flewelling; Jacob P MacDonald; Catherine R Downey; Eric A Cohen; Erin T Pelkey
Journal:  J Org Chem       Date:  2011-09-26       Impact factor: 4.354

Review 4.  A comprehensive review of glycosylated bacterial natural products.

Authors:  Sherif I Elshahawi; Khaled A Shaaban; Madan K Kharel; Jon S Thorson
Journal:  Chem Soc Rev       Date:  2015-11-07       Impact factor: 54.564

5.  The effect of K-252a, a potent microbial inhibitor of protein kinase, on activated cyclic nucleotide phosphodiesterase.

Authors:  Y Matsuda; S Nakanishi; K Nagasawa; K Iwahashi; H Kase
Journal:  Biochem J       Date:  1988-11-15       Impact factor: 3.857

6.  Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase.

Authors:  Aaroa P Salas; Lili Zhu; César Sánchez; Alfredo F Braña; Jürgen Rohr; Carmen Méndez; José A Salas
Journal:  Mol Microbiol       Date:  2005-10       Impact factor: 3.501

7.  Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691.

Authors:  Khaled A Shaaban; Sherif I Elshahawi; Xiachang Wang; Jamie Horn; Madan K Kharel; Markos Leggas; Jon S Thorson
Journal:  J Nat Prod       Date:  2015-06-19       Impact factor: 4.050

8.  Characterization of a staurosporine- and temperature-sensitive mutant, stt1, of Saccharomyces cerevisiae: STT1 is allelic to PKC1.

Authors:  S Yoshida; E Ikeda; I Uno; H Mitsuzawa
Journal:  Mol Gen Genet       Date:  1992-02

9.  Effects of protein kinase inhibitors on in vitro protein phosphorylation and cellular differentiation of Streptomyces griseus.

Authors:  S K Hong; A Matsumoto; S Horinouchi; T Beppu
Journal:  Mol Gen Genet       Date:  1993-01

10.  Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp.

Authors:  P A Horton; R E Longley; O J McConnell; L M Ballas
Journal:  Experientia       Date:  1994-09-15
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