Literature DB >> 7903681

Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival.

L Qin1, K D Chavin, J Lin, H Yagita, J S Bromberg.   

Abstract

Indefinite graft survival was obtained with murine cardiac allografts using the combined administration of monoclonal antibodies (mAbs) directed against the receptor ligand pair CD2-CD48. Although each antibody could prolong graft survival when given alone, neither resulted in the indefinite graft survival seen with the combination. Combined mAb administration is associated with inhibition of T cell priming and help and subsequent cytotoxic T lymphocyte generation. This indicates that the interaction between CD2 and its ligand is important for antigen priming and recognition, and combined mAbs may prove to be a useful therapeutic regimen for transplantation.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7903681      PMCID： PMC2191341          DOI： 10.1084/jem.179.1.341

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  25 in total

1.  Phytohemagglutinin-induced proliferation of guinea pig thymus-derived lymphocytes. I. Accessory cell dependence.

Authors:  P E Lipsky; J J Ellner; A L Rosenthal
Journal:  J Immunol       Date:  1976-03       Impact factor: 5.422

Review 2.  Inflammation-induced endothelial cell adhesion to lymphocytes, neutrophils, and monocytes. Role of homing receptors and other adhesion molecules.

Authors:  M A Jutila; E L Berg; T K Kishimoto; L J Picker; R F Bargatze; D K Bishop; C G Orosz; N W Wu; E C Butcher
Journal:  Transplantation       Date:  1989-11       Impact factor: 4.939

Review 3.  Lymphocyte interactions with extracellular matrix.

Authors:  Y Shimizu; S Shaw
Journal:  FASEB J       Date:  1991-06       Impact factor: 5.191

4.  Cardiac transplantation in mice. I. Factors influencing the take and survival of heterotopic grafts.

Authors:  K P Judd; J J Trentin
Journal:  Transplantation       Date:  1971-03       Impact factor: 4.939

5.  Antibody 12-15 cross-reacts with mouse Fc gamma receptors and CD2: study of thymus expression, genetic polymorphism and biosynthesis of the CD2 protein.

Authors:  P Altevogt; U Kohl; P Von Hoegen; E Lang; V Schirrmacher
Journal:  Eur J Immunol       Date:  1989-02       Impact factor: 5.532

6.  Monoclonal antibodies to the p21 products of the transforming gene of Harvey murine sarcoma virus and of the cellular ras gene family.

Authors:  M E Furth; L J Davis; B Fleurdelys; E M Scolnick
Journal:  J Virol       Date:  1982-07       Impact factor: 5.103

7.  Continuous proliferation of murine antigen-specific helper T lymphocytes in culture.

Authors:  J Watson
Journal:  J Exp Med       Date:  1979-12-01       Impact factor: 14.307

8.  Anti-CD2 antibodies induce T cell unresponsiveness in vivo.

Authors:  B Gückel; C Berek; M Lutz; P Altevogt; V Schirrmacher; B A Kyewski
Journal:  J Exp Med       Date:  1991-11-01       Impact factor: 14.307

9.  Induction of classical transplantation tolerance in the adult.

Authors:  S X Qin; S Cobbold; R Benjamin; H Waldmann
Journal:  J Exp Med       Date:  1989-03-01       Impact factor: 14.307

10.  Monoclonal cytolytic T-cell lines.

Authors:  P E Baker; S Gillis; K A Smith
Journal:  J Exp Med       Date:  1979-01-01       Impact factor: 14.307
View more
  13 in total

1.  Functional glycan-free adhesion domain of human cell surface receptor CD58: design, production and NMR studies.

Authors:  Z Y Sun; V Dötsch; M Kim; J Li; E L Reinherz; G Wagner
Journal:  EMBO J       Date:  1999-06-01       Impact factor: 11.598

2.  Structure-activity studies of peptides from the "hot-spot" region of human CD2 protein: development of peptides for immunomodulation.

Authors:  Jining Liu; Jinfa Ying; Vincent T K Chow; Victor J Hruby; Seetharama D Satyanarayanajois
Journal:  J Med Chem       Date:  2005-10-06       Impact factor: 7.446

3.  The counterreceptor binding site of human CD2 exhibits an extended surface patch with multiple conformations fluctuating with millisecond to microsecond motions.

Authors:  D F Wyss; K T Dayie; G Wagner
Journal:  Protein Sci       Date:  1997-03       Impact factor: 6.725

4.  Enhancement of antigen-specific immunoglobulin G responses by anti-CD48.

Authors:  Dorothy Yuan; Yuhong Guo; Suwannee Thet
Journal:  J Innate Immun       Date:  2012-11-27       Impact factor: 7.349

5.  Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4+ T Cells.

Authors:  Shannon L McArdel; Daniel R Brown; Raymond A Sobel; Arlene H Sharpe
Journal:  J Immunol       Date:  2016-08-31       Impact factor: 5.422

6.  CD48 is critically involved in allergic eosinophilic airway inflammation.

Authors:  Ariel Munitz; Ido Bachelet; Fred D Finkelman; Marc E Rothenberg; Francesca Levi-Schaffer
Journal:  Am J Respir Crit Care Med       Date:  2007-02-08       Impact factor: 21.405

Review 7.  Roles of CD48 in regulating immunity and tolerance.

Authors:  Shannon L McArdel; Cox Terhorst; Arlene H Sharpe
Journal:  Clin Immunol       Date:  2016-01-18       Impact factor: 3.969

8.  CD48-deficient mice have a pronounced defect in CD4(+) T cell activation.

Authors:  J González-Cabrero; C J Wise; Y Latchman; G J Freeman; A H Sharpe; H Reiser
Journal:  Proc Natl Acad Sci U S A       Date:  1999-02-02       Impact factor: 11.205

Review 9.  CD58 Immunobiology at a Glance.

Authors:  Yalu Zhang; Qiaofei Liu; Sen Yang; Quan Liao
Journal:  Front Immunol       Date:  2021-06-08       Impact factor: 7.561

10.  2B4, the natural killer and T cell immunoglobulin superfamily surface protein, is a ligand for CD48.

Authors:  M H Brown; K Boles; P A van der Merwe; V Kumar; P A Mathew; A N Barclay
Journal:  J Exp Med       Date:  1998-12-07       Impact factor: 14.307
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.