OBJECTIVE: The MR findings in a characteristic pattern of hypoxic-ischemic brain damage in term infants are described. MATERIALS AND METHODS: The MR images of seven patients with cerebral palsy and a specific pattern of central cortico-subcortical cerebral damage were studied retrospectively and correlated with clinical findings. RESULTS: All seven patients were born at term. Five of the seven patients had a clear history of severe perinatal asphyxia. All children had severe encephalopathic symptomatology, including spastic tetraplegia, extrapyramidal symptoms, and a mental deficit. The MR showed localized atrophy of the cortex and in addition cystic changes, gliosis, and tissue loss of the adjacent white matter. In all patients, the lesions were band shaped in the left-right direction and characteristically located in areas bordering the central sulcus. The segment of the corpus callosum underlying the affected area was always thin. In some patients, lesions were also found bilaterally in the occipital regions, hippocampus, and basal ganglia. The areas involved match the regions that are known to show active myelination on MR in the term neonate. CONCLUSION: Recognition of this specific pattern on MR in children with cerebral palsy enables the classification of such lesions as resulting from peri- or postnatal asphyxia, even if the perinatal history is unknown or equivocal, and makes other etiologies less likely.
OBJECTIVE: The MR findings in a characteristic pattern of hypoxic-ischemic brain damage in term infants are described. MATERIALS AND METHODS: The MR images of seven patients with cerebral palsy and a specific pattern of central cortico-subcortical cerebral damage were studied retrospectively and correlated with clinical findings. RESULTS: All seven patients were born at term. Five of the seven patients had a clear history of severe perinatal asphyxia. All children had severe encephalopathic symptomatology, including spastic tetraplegia, extrapyramidal symptoms, and a mental deficit. The MR showed localized atrophy of the cortex and in addition cystic changes, gliosis, and tissue loss of the adjacent white matter. In all patients, the lesions were band shaped in the left-right direction and characteristically located in areas bordering the central sulcus. The segment of the corpus callosum underlying the affected area was always thin. In some patients, lesions were also found bilaterally in the occipital regions, hippocampus, and basal ganglia. The areas involved match the regions that are known to show active myelination on MR in the term neonate. CONCLUSION: Recognition of this specific pattern on MR in children with cerebral palsy enables the classification of such lesions as resulting from peri- or postnatal asphyxia, even if the perinatal history is unknown or equivocal, and makes other etiologies less likely.
Authors: L Liauw; I H Palm-Meinders; J van der Grond; L M Leijser; S le Cessie; L A E M Laan; B C Heeres; M A van Buchem; G van Wezel-Meijler Journal: AJNR Am J Neuroradiol Date: 2007-04 Impact factor: 3.825
Authors: L T Sie; M S van der Knaap; G van Wezel-Meijler; A H Taets van Amerongen; H N Lafeber; J Valk Journal: AJNR Am J Neuroradiol Date: 2000-05 Impact factor: 4.966
Authors: Thomas Alderliesten; Linda S de Vries; Yara Khalil; Ingrid C van Haastert; Manon J N L Benders; Corine Koopman-Esseboom; Floris Groenendaal Journal: PLoS One Date: 2015-04-29 Impact factor: 3.240