Birol Karabulut1, Begum Sahbudak1. 1. Karabulut, Izmir Katip Celebi University Ataturk Training and Research Hospital, Department of Pediatrics, Division of Neonatology, Izmir, Turkey. Sahbudak, Izmir Katip Celebi University Ataturk Training and Research Hospital, Department of Child and Adolescent Psychiatry.
Abstract
Background: Hypoxia, acidosis, and inflammation cause impairment of neuronal development due to lack of sufficient oxygen and nutrition, and there may be an increased risk of ASD in neonates with Neonatal Encephalopathy (NE). To evaluate the frequency of Autism Spectrum Disorder (ASD) in moderate and severe NE requiring therapeutic hypothermia at 18-36 months. Methods: In this prospective study, infants with moderate and severe NE requiring hypothermia were included. Results: Throughout the study period, 33 of 85 neonates with NE admitted to our unit were included in the study. M-CHAT results of six infants included in the study showed positive and results of twenty-seven patients were negative. Four of six infants with a positive screening test completed a psychiatric examination, and two infants did not complete the clinical examination. The results of the examination showed that one infant was diagnosed with ASD, one was diagnosed with attention deficit hyperactivity disorder (ADHD), and two infants were diagnosed with no psychiatric disorder. Conclusion: Our results showed that the risk of ASD increases in infants with moderate and severe NE, and this relationship should be considered in long-term clinical follow-ups.
Background: Hypoxia, acidosis, and inflammation cause impairment of neuronal development due to lack of sufficient oxygen and nutrition, and there may be an increased risk of ASD in neonates with Neonatal Encephalopathy (NE). To evaluate the frequency of Autism Spectrum Disorder (ASD) in moderate and severe NE requiring therapeutic hypothermia at 18-36 months. Methods: In this prospective study, infants with moderate and severe NE requiring hypothermia were included. Results: Throughout the study period, 33 of 85 neonates with NE admitted to our unit were included in the study. M-CHAT results of six infants included in the study showed positive and results of twenty-seven patients were negative. Four of six infants with a positive screening test completed a psychiatric examination, and two infants did not complete the clinical examination. The results of the examination showed that one infant was diagnosed with ASD, one was diagnosed with attention deficit hyperactivity disorder (ADHD), and two infants were diagnosed with no psychiatric disorder. Conclusion: Our results showed that the risk of ASD increases in infants with moderate and severe NE, and this relationship should be considered in long-term clinical follow-ups.
Authors: Michele C Walsh; Edward F Bell; Sarah Kandefer; Shampa Saha; Waldemar A Carlo; Carl T D'angio; Abbot R Laptook; Pablo J Sanchez; Barbara J Stoll; Seetha Shankaran; Krisa P Van Meurs; Noah Cook; Rosemary D Higgins; Abhik Das; Nancy S Newman; Kurt Schibler; Barbara Schmidt; C Michael Cotten; Brenda B Poindexter; Kristi L Watterberg; William E Truog Journal: Pediatr Res Date: 2017-05-24 Impact factor: 3.756