Literature DB >> 7869408

The Tuskegee Syphilis Experiment: biotechnology and the administrative state.

B Roy1.   

Abstract

The central issue of the Tuskegee Syphilis Experiment was property: property in the body and intellectual property. Once removed from the body, tissue and body fluids were not legally the property of the Tuskegee subjects. Consequently, there was not a direct relationship between a patient and research that used his sera. The Public Health Service (PHS) was free to exercise its property right in Tuskegee sera to develop serologic tests for syphilis with commercial potential. To camouflage the true meaning, the PHS made a distinction between direct clinical studies and indirect studies of tissue and body fluids. This deception caused all reviews to date to limit their examination to documents labeled by the PHS as directly related to the Tuskegee Syphilis Experiment. This excluded other information in the public domain. Despite the absence of a clinical protocol, this subterfuge led each to falsely conclude that the Tuskagee Syphilis Experiment was a clinical study. Based on publications of indirect research using sera and cerebrospinal fluid, this article conceives a very history of the Tuskagee Syphilis Experiment. Syphilis could only cultivate in living beings. As in slavery, the generative ability of the body made the Tuskegee subjects real property and gave untreated syphilis and the sera of the Tuskegee subjects immense commercial value. Published protocols exploited the Tuskegee Syphilis Experiment to invent and commercialize biotechnology for the applied science of syphilis serology.

Entities:  

Keywords:  Biomedical and Behavioral Research; Public Health Service; Tuskegee Syphilis Study; Twentieth Century

Mesh:

Year:  1995        PMID: 7869408      PMCID: PMC2607737     

Source DB:  PubMed          Journal:  J Natl Med Assoc        ISSN: 0027-9684            Impact factor:   1.798


  23 in total

1.  Fluorescent treponemal antibody test. Modification based on quantitation (FTA-200).

Authors:  W E DEACON; E M FREEMAN; A HARRIS
Journal:  Proc Soc Exp Biol Med       Date:  1960-04

2.  The Reiter protein antigen test compared with the TPI and other treponemal and nontreponemal antigen technics in the diagnosis of syphilis.

Authors:  W J BROWN; E V PRICE; W G SIMPSON
Journal:  J Invest Dermatol       Date:  1960-03       Impact factor: 8.551

3.  Isothiocyanate compounds as fluorescent labeling agents for immune serum.

Authors:  J L RIGGS; R J SEIWALD; J H BURCKHALTER; C M DOWNS; T G METCALF
Journal:  Am J Pathol       Date:  1958 Nov-Dec       Impact factor: 4.307

4.  A fluorescent test for treponemal antibodies.

Authors:  W E DEACON; V H FALCONE; A HARRIS
Journal:  Proc Soc Exp Biol Med       Date:  1957-11

5.  A preliminary study of apparent biological flase positive reactions in four serological tests for syphilis, and the treponemal immobilization test.

Authors:  S OLANSKY; A HARRIS; J H HILL
Journal:  Am J Syph Gonorrhea Vener Dis       Date:  1953-01

6.  Factors affecting the survival of Treponema pallidum in vitro.

Authors:  R A NELSON
Journal:  Am J Hyg       Date:  1948-07

7.  Untreated syphilis in the male Negro; observation of abnormalities over 16 years.

Authors:  P J PESARE; T J BAUER; G A GLEESON
Journal:  Am J Syph Gonorrhea Vener Dis       Date:  1950-05

8.  Treponemal haemagglutination test.

Authors:  P J Sequeira; A E Eldridge
Journal:  Br J Vener Dis       Date:  1973-06

9.  EXPERIMENTAL SYPHILIS IN THE RABBIT PRODUCED BY THE BRAIN SUBSTANCE OF THE LIVING PARETIC.

Authors:  U J Wile
Journal:  J Exp Med       Date:  1916-02-01       Impact factor: 14.307

10.  Immobilization of Treponema pallidum in vitro by antibody produced in syphilitic infection.

Authors:  R A NELSON; M M MAYER
Journal:  J Exp Med       Date:  1949-04-01       Impact factor: 14.307

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  8 in total

1.  The Tuskegee Study of Untreated Syphilis and public perceptions of biomedical research: a focus group study.

Authors:  Benjamin R Bates; Tina M Harris
Journal:  J Natl Med Assoc       Date:  2004-08       Impact factor: 1.798

2.  Cultural Competence Considerations for Health-System Pharmacists.

Authors:  Megan Park Corsi; Joel D Jackson; Bryan C McCarthy
Journal:  Hosp Pharm       Date:  2018-11-02

3.  From in vivo to in vitro: How the Guatemala STD Experiments Transformed Bodies Into Biospecimens.

Authors:  Kayte Spector-Bagdady; Paul A Lombardo
Journal:  Milbank Q       Date:  2018-04-13       Impact factor: 4.911

4.  Discrimination and Medical Mistrust in a Racially and Ethnically Diverse Sample of California Adults.

Authors:  Mohsen Bazargan; Sharon Cobb; Shervin Assari
Journal:  Ann Fam Med       Date:  2021 Jan-Feb       Impact factor: 5.166

5.  The Julius Rosenwald Fund syphilis seroprevalence studies.

Authors:  B Roy
Journal:  J Natl Med Assoc       Date:  1996-05       Impact factor: 1.798

6.  Tuskegee redux: evolution of legal mandates for human experimentation.

Authors:  Robert S Levine; Jamila C Williams; Barbara A Kilbourne; Paul D Juarez
Journal:  J Health Care Poor Underserved       Date:  2012-11

7.  Why would a black man volunteer for a government-funded science experiment?

Authors:  Edjah K Nduom
Journal:  EClinicalMedicine       Date:  2021-03-19

Review 8.  Disparities in Palliative and Hospice Care and Completion of Advance Care Planning and Directives Among Non-Hispanic Blacks: A Scoping Review of Recent Literature.

Authors:  Mohsen Bazargan; Shahrzad Bazargan-Hejazi
Journal:  Am J Hosp Palliat Care       Date:  2020-12-08       Impact factor: 2.500

  8 in total

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