Literature DB >> 7862159

Meiosis-specific double-strand DNA breaks at the HIS4 recombination hot spot in the yeast Saccharomyces cerevisiae: control in cis and trans.

Q Fan1, F Xu, T D Petes.   

Abstract

The region of Saccharomyces cerevisiae chromosome III located between the 5' end of the HIS4 gene and the 3' end of the adjacent BIK1 gene has a very high level of meiotic recombination. In wild-type strains, a meiosis-specific double-strand DNA break occurs in the hot spot region. This break is absent in strains in which the transcription factors Rap1p, Bas1p, and Bas2p cannot bind to the region upstream of HIS4. In strains with levels of recombination that are higher than those of the wild type, the break is found at elevated levels. The linear relationship between hot spot activity and the frequency of double-strand DNA breaks suggests that these lesions are responsible for initiating recombination at the HIS4 recombination hot spot.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7862159      PMCID： PMC230392          DOI： 10.1128/MCB.15.3.1679

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  43 in total

1.  Decreasing gradients of gene conversion on both sides of the initiation site for meiotic recombination at the ARG4 locus in yeast.

Authors:  N P Schultes; J W Szostak
Journal:  Genetics       Date:  1990-12       Impact factor: 4.562

2.  GCN4 protein, a positive transcription factor in yeast, binds general control promoters at all 5' TGACTC 3' sequences.

Authors:  K Arndt; G R Fink
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

3.  Replacement of chromosome segments with altered DNA sequences constructed in vitro.

Authors:  S Scherer; R W Davis
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

4.  A short chromosomal region with major roles in yeast chromosome III meiotic disjunction, recombination and double strand breaks.

Authors:  M Goldway; A Sherman; D Zenvirth; T Arbel; G Simchen
Journal:  Genetics       Date:  1993-02       Impact factor: 4.562

5.  Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination.

Authors:  E Alani; R Padmore; N Kleckner
Journal:  Cell       Date:  1990-05-04       Impact factor: 41.582

6.  Meiosis-induced double-strand break sites determined by yeast chromatin structure.

Authors:  T C Wu; M Lichten
Journal:  Science       Date:  1994-01-28       Impact factor: 47.728

7.  Multiple global regulators control HIS4 transcription in yeast.

Authors:  K T Arndt; C Styles; G R Fink
Journal:  Science       Date:  1987-08-21       Impact factor: 47.728

8.  Seven-base-pair inverted repeats in DNA form stable hairpins in vivo in Saccharomyces cerevisiae.

Authors:  D K Nag; T D Petes
Journal:  Genetics       Date:  1991-11       Impact factor: 4.562

9.  Analysis of a recombination hotspot for gene conversion occurring at the HIS2 gene of Saccharomyces cerevisiae.

Authors:  R E Malone; S Kim; S A Bullard; S Lundquist; L Hutchings-Crow; S Cramton; L Lutfiyya; J Lee
Journal:  Genetics       Date:  1994-05       Impact factor: 4.562

10.  DNA sequence analysis of the ade6 gene of Schizosaccharomyces pombe. Wild-type and mutant alleles including the recombination host spot allele ade6-M26.

Authors:  P Szankasi; W D Heyer; P Schuchert; J Kohli
Journal:  J Mol Biol       Date:  1988-12-20       Impact factor: 5.469
View more
  74 in total

1.  The conversion gradient at HIS4 of Saccharomyces cerevisiae. I. Heteroduplex rejection and restoration of Mendelian segregation.

Authors:  K J Hillers; F W Stahl
Journal:  Genetics       Date:  1999-10       Impact factor: 4.562

2.  Maximal stimulation of meiotic recombination by a yeast transcription factor requires the transcription activation domain and a DNA-binding domain.

Authors:  D T Kirkpatrick; Q Fan; T D Petes
Journal:  Genetics       Date:  1999-05       Impact factor: 4.562

3.  Coordination of the initiation of recombination and the reductional division in meiosis in Saccharomyces cerevisiae.

Authors:  K Jiao; S A Bullard; L Salem; R E Malone
Journal:  Genetics       Date:  1999-05       Impact factor: 4.562

4.  Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae.

Authors:  J L Gerton; J DeRisi; R Shroff; M Lichten; P O Brown; T D Petes
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-10       Impact factor: 11.205

5.  Targeted DNA integration within different functional gene domains in yeast reveals ORF sequences as recombinational cold-spots.

Authors:  K Gjuracic; E Pivetta; C V Bruschi
Journal:  Mol Genet Genomics       Date:  2004-03-27       Impact factor: 3.291

6.  High-Resolution Global Analysis of the Influences of Bas1 and Ino4 Transcription Factors on Meiotic DNA Break Distributions in Saccharomyces cerevisiae.

Authors:  Xuan Zhu; Scott Keeney
Journal:  Genetics       Date:  2015-08-05       Impact factor: 4.562

7.  Patterns of meiotic double-strand breakage on native and artificial yeast chromosomes.

Authors:  S Klein; D Zenvirth; V Dror; A B Barton; D B Kaback; G Simchen
Journal:  Chromosoma       Date:  1996-12       Impact factor: 4.316

8.  Triplet repeats form secondary structures that escape DNA repair in yeast.

Authors:  H Moore; P W Greenwell; C P Liu; N Arnheim; T D Petes
Journal:  Proc Natl Acad Sci U S A       Date:  1999-02-16       Impact factor: 11.205

9.  Recombination events in Neurospora crassa may cross a translocation breakpoint by a template-switching mechanism.

Authors:  P J Yeadon; J P Rasmussen; D E Catcheside
Journal:  Genetics       Date:  2001-10       Impact factor: 4.562

10.  Meiotic recombination at the ends of chromosomes in Saccharomyces cerevisiae.

Authors:  Arnold B Barton; Michael R Pekosz; Rohini S Kurvathi; David B Kaback
Journal:  Genetics       Date:  2008-06-18       Impact factor: 4.562
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.