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Literature DB >> 11027339

Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae.

J L Gerton¹, J DeRisi, R Shroff, M Lichten, P O Brown, T D Petes.

Abstract

In the yeast Saccharomyces cerevisiae, meiotic recombination is initiated by double-strand DNA breaks (DSBs). Meiotic DSBs occur at relatively high frequencies in some genomic regions (hotspots) and relatively low frequencies in others (coldspots). We used DNA microarrays to estimate variation in the level of nearby meiotic DSBs for all 6,200 yeast genes. Hotspots were nonrandomly associated with regions of high G + C base composition and certain transcriptional profiles. Coldspots were nonrandomly associated with the centromeres and telomeres.

Entities: Species

Mesh：

Substances：
DNA Primers

Year: 2000 PMID： 11027339 PMCID： PMC17209 DOI： 10.1073/pnas.97.21.11383

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

32 in total

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Authors: S Klein; D Zenvirth; V Dror; A B Barton; D B Kaback; G Simchen
Journal: Chromosoma Date: 1996-12 Impact factor: 4.316

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Journal: Cell Date: 1998-11-25 Impact factor: 41.582

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Authors: M Lichten; A S Goldman
Journal: Annu Rev Genet Date: 1995 Impact factor: 16.830

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Authors: S Keeney; C N Giroux; N Kleckner
Journal: Cell Date: 1997-02-07 Impact factor: 41.582

Review 5. The yeast genome project: what did we learn?

Authors: B Dujon
Journal: Trends Genet Date: 1996-07 Impact factor: 11.639

6. Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae.

Authors: M A White; M Dominska; T D Petes
Journal: Proc Natl Acad Sci U S A Date: 1993-07-15 Impact factor: 11.205

7. Analysis of replication origin function on chromosome III of Saccharomyces cerevisiae.

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Journal: Cold Spring Harb Symp Quant Biol Date: 1993

8. SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast.

Authors: S Strahl-Bolsinger; A Hecht; K Luo; M Grunstein
Journal: Genes Dev Date: 1997-01-01 Impact factor: 11.361

9. Factors that affect the location and frequency of meiosis-induced double-strand breaks in Saccharomyces cerevisiae.

Authors: T C Wu; M Lichten
Journal: Genetics Date: 1995-05 Impact factor: 4.562

10. Meiosis-specific double-strand DNA breaks at the HIS4 recombination hot spot in the yeast Saccharomyces cerevisiae: control in cis and trans.

Authors: Q Fan; F Xu; T D Petes
Journal: Mol Cell Biol Date: 1995-03 Impact factor: 4.272

252 in total

1. A function for subtelomeric DNA in Saccharomyces cerevisiae.

Authors: Arnold B Barton; Yuping Su; Jacque Lamb; Dianna Barber; David B Kaback
Journal: Genetics Date: 2003-10 Impact factor: 4.562

2. A neutral explanation for the correlation of diversity with recombination rates in humans.

Authors: Ines Hellmann; Ingo Ebersberger; Susan E Ptak; Svante Pääbo; Molly Przeworski
Journal: Am J Hum Genet Date: 2003-05-08 Impact factor: 11.025

3. Roles of mutation and recombination in the evolution of protein thermodynamics.

Authors: Yu Xia; Michael Levitt
Journal: Proc Natl Acad Sci U S A Date: 2002-07-29 Impact factor: 11.205

4. Close, stable homolog juxtaposition during meiosis in budding yeast is dependent on meiotic recombination, occurs independently of synapsis, and is distinct from DSB-independent pairing contacts.

Authors: Tamara L Peoples; Eric Dean; Oscar Gonzalez; Lindsey Lambourne; Sean M Burgess
Journal: Genes Dev Date: 2002-07-01 Impact factor: 11.361

5. Targeted DNA integration within different functional gene domains in yeast reveals ORF sequences as recombinational cold-spots.

Authors: K Gjuracic; E Pivetta; C V Bruschi
Journal: Mol Genet Genomics Date: 2004-03-27 Impact factor: 3.291