Literature DB >> 7857588

Locomotor inhibition by the D3 ligand R-(+)-7-OH-DPAT is independent of changes in dopamine release.

K Svensson1, A Carlsson, N Waters.   

Abstract

The dopamine D3 preferring ligand R-(+)-7-OH-DPAT induced strong hypolocomotion in rats. Doses producing reduction of locomotion failed to affect dopamine release or synthesis rate. These data support the hypothesis that the dopamine D3 receptor is a postsynaptic receptor with an inhibitory influence on rat locomotor activity.

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Year:  1994        PMID： 7857588     DOI： 10.1007/bf01283032

Source DB:  PubMed          Journal:  J Neural Transm Gen Sect


  7 in total

Review 1.  Do autoreceptors mediate dopamine agonist--induced yawning and suppression of exploration? A critical review.

Authors:  L Ståhle
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

2.  Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.

Authors:  P Sokoloff; B Giros; M P Martres; M L Bouthenet; J C Schwartz
Journal:  Nature       Date:  1990-09-13       Impact factor: 49.962

3.  Pharmacological aspects of R-(+)-7-OH-DPAT, a putative dopamine D3 receptor ligand.

Authors:  G Damsma; T Bottema; B H Westerink; P G Tepper; D Dijkstra; T A Pugsley; R G MacKenzie; T G Heffner; H Wikström
Journal:  Eur J Pharmacol       Date:  1993-11-16       Impact factor: 4.432

4.  Behavioural effects of the putative D-3 dopamine receptor agonist 7-OH-DPAT in relation to other "D-2-like" agonists.

Authors:  S A Daly; J L Waddington
Journal:  Neuropharmacology       Date:  1993-05       Impact factor: 5.250

5.  The dopamine D3-receptor: a postsynaptic receptor inhibitory on rat locomotor activity.

Authors:  N Waters; K Svensson; S R Haadsma-Svensson; M W Smith; A Carlsson
Journal:  J Neural Transm Gen Sect       Date:  1993

6.  The dopamine D3 receptor and autoreceptor preferring antagonists (+)-AJ76 and (+)-UH232; a microdialysis study.

Authors:  N Waters; S Lagerkvist; L Löfberg; M Piercey; A Carlsson
Journal:  Eur J Pharmacol       Date:  1993-09-28       Impact factor: 4.432

7.  Resolved monophenolic 2-aminotetralins and 1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolines: structural and stereochemical considerations for centrally acting pre- and postsynaptic dopamine-receptor agonists.

Authors:  H Wikström; B Andersson; D Sanchez; P Lindberg; L E Arvidsson; A M Johansson; J L Nilsson; K Svensson; S Hjorth; A Carlsson
Journal:  J Med Chem       Date:  1985-02       Impact factor: 7.446
  7 in total
  23 in total

Review 1.  Dopamine D3 receptor: A neglected participant in Parkinson Disease pathogenesis and treatment?

Authors:  Pengfei Yang; Joel S Perlmutter; Tammie L S Benzinger; John C Morris; Jinbin Xu
Journal:  Ageing Res Rev       Date:  2019-11-22       Impact factor: 10.895

2.  Food restriction alters N'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (pramipexole)-induced yawning, hypothermia, and locomotor activity in rats: evidence for sensitization of dopamine D2 receptor-mediated effects.

Authors:  Gregory T Collins; Diane M Calinski; Amy Hauck Newman; Peter Grundt; James H Woods
Journal:  J Pharmacol Exp Ther       Date:  2008-02-27       Impact factor: 4.030

3.  Effects of dopamine D3 preferring compounds on conditioned place preference and intracranial self-stimulation in the rat.

Authors:  T Kling-Petersen; E Ljung; L Wollter; K Svensson
Journal:  J Neural Transm Gen Sect       Date:  1995

4.  Dose-dependent effects of the D3-preferring agonist 7-OH-DPAT on motor behaviors and place conditioning.

Authors:  T V Khroyan; D A Baker; J L Neisewander
Journal:  Psychopharmacology (Berl)       Date:  1995-12       Impact factor: 4.530

5.  Repeated 7-OH-DPAT treatments: behavioral sensitization, dopamine synthesis and subsequent sensitivity to apomorphine and cocaine.

Authors:  B A Mattingly; S E Fields; M S Langfels; J K Rowlett; P M Robinet; M T Bardo
Journal:  Psychopharmacology (Berl)       Date:  1996-05       Impact factor: 4.530

6.  Imaging brain regional and cortical laminar effects of selective D3 agonists and antagonists.

Authors:  Ji-Kyung Choi; Joseph B Mandeville; Y Iris Chen; Peter Grundt; Susanta K Sarkar; Amy H Newman; Bruce G Jenkins
Journal:  Psychopharmacology (Berl)       Date:  2010-07-14       Impact factor: 4.530

7.  NMDA or AMPA/kainate receptor blockade prevents acquisition of conditioned place preference induced by D(2/3) dopamine receptor stimulation in rats.

Authors:  Anna-Maria Biondo; Robert L H Clements; David J Hayes; Brendan Eshpeter; Andrew J Greenshaw
Journal:  Psychopharmacology (Berl)       Date:  2005-03-03       Impact factor: 4.530

8.  Phenylpiperazine derivatives with selectivity for dopamine D3 receptors modulate cocaine self-administration in rats.

Authors:  T H C Cheung; B C Nolan; L R Hammerslag; S M Weber; J P Durbin; N A Peartree; R H Mach; R R Luedtke; J L Neisewander
Journal:  Neuropharmacology       Date:  2012-08-31       Impact factor: 5.250

9.  Differential effects of dopamine D2 and D3 receptor antagonists in regard to dopamine release, in vivo receptor displacement and behaviour.

Authors:  N Waters; L Löfberg; S Haadsma-Svensson; K Svensson; C Sonesson; A Carlsson
Journal:  J Neural Transm Gen Sect       Date:  1994

10.  Neuropharmacological evidence for the role of dopamine in ventral pallidum self-stimulation.

Authors:  G Panagis; C Spyraki
Journal:  Psychopharmacology (Berl)       Date:  1996-02       Impact factor: 4.530
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