Literature DB >> 8129881

The dopamine D3-receptor: a postsynaptic receptor inhibitory on rat locomotor activity.

N Waters1, K Svensson, S R Haadsma-Svensson, M W Smith, A Carlsson.   

Abstract

We report on the pharmacological effects of the 20 fold D3 vs. D2 dopamine receptor preferring compound U99194A. It is shown that U99194A increases rat locomotor activity at doses that do not increase release or utilisation of dopamine in the striatum or the nucleus accumbens significantly. The data do not support any direct agonist action of U99194A at dopamine receptors. It is suggested that U99194A can antagonise a population of postsynaptic dopamine receptors involved in the suppression of some aspects of psychomotor activity. These postsynaptic receptors presumably belong to the D3 receptor subtype.

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Year:  1993        PMID： 8129881     DOI： 10.1007/bf01244979

Source DB:  PubMed          Journal:  J Neural Transm Gen Sect


  20 in total

Review 1.  Do autoreceptors mediate dopamine agonist--induced yawning and suppression of exploration? A critical review.

Authors:  L Ståhle
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

2.  Pharmacology. The dopamine connection.

Authors:  S H Snyder
Journal:  Nature       Date:  1990-09-13       Impact factor: 49.962

3.  Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics.

Authors:  P Sokoloff; B Giros; M P Martres; M L Bouthenet; J C Schwartz
Journal:  Nature       Date:  1990-09-13       Impact factor: 49.962

4.  Behavioural effects of the putative D-3 dopamine receptor agonist 7-OH-DPAT in relation to other "D-2-like" agonists.

Authors:  S A Daly; J L Waddington
Journal:  Neuropharmacology       Date:  1993-05       Impact factor: 5.250

5.  Effect of ethanol on the hydroxylation of tyrosine and tryptophan in rat brain in vivo.

Authors:  A Carlsson; M Lindqvist
Journal:  J Pharm Pharmacol       Date:  1973-06       Impact factor: 3.765

6.  Intrinsic activity determinations at the dopamine D2 guanine nucleotide-binding protein-coupled receptor: utilization of receptor state binding affinities.

Authors:  R A Lahti; L M Figur; M F Piercey; P L Ruppel; D L Evans
Journal:  Mol Pharmacol       Date:  1992-09       Impact factor: 4.436

7.  Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor.

Authors:  P Sokoloff; M Andrieux; R Besançon; C Pilon; M P Martres; B Giros; J C Schwartz
Journal:  Eur J Pharmacol       Date:  1992-04-10       Impact factor: 4.432

8.  Modulation of cocaine self-administration in the rat through D-3 dopamine receptors.

Authors:  S B Caine; G F Koob
Journal:  Science       Date:  1993-06-18       Impact factor: 47.728

9.  Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3H]hydroxy-N,N-di-n-propyl-2-aminotetralin.

Authors:  D Lévesque; J Diaz; C Pilon; M P Martres; B Giros; E Souil; D Schott; J L Morgat; J C Schwartz; P Sokoloff
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-01       Impact factor: 11.205

10.  Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNA.

Authors:  M L Bouthenet; E Souil; M P Martres; P Sokoloff; B Giros; J C Schwartz
Journal:  Brain Res       Date:  1991-11-15       Impact factor: 3.252
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  45 in total

1.  Crucial role of the accumbens nucleus in the neurotransmitter interactions regulating motor control in mice.

Authors:  A Svensson; M L Carlsson; A Carlsson
Journal:  J Neural Transm Gen Sect       Date:  1995

2.  Dopamine D3 receptor antagonists improve the learning performance in memory-impaired rats.

Authors:  Judit Laszy; István Laszlovszky; István Gyertyán
Journal:  Psychopharmacology (Berl)       Date:  2004-12-24       Impact factor: 4.530

Review 3.  The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence.

Authors:  Christian A Heidbreder; Eliot L Gardner; Zheng-Xiong Xi; Panayotis K Thanos; Manolo Mugnaini; Jim J Hagan; Charles R Ashby
Journal:  Brain Res Brain Res Rev       Date:  2005-07

4.  Effects of (-)-OSU6162 and ACR16 on motor activity in rats, indicating a unique mechanism of dopaminergic stabilization.

Authors:  Johan P Rung; Emilia Rung; Lisa Helgeson; Anette M Johansson; Kjell Svensson; Arvid Carlsson; Maria L Carlsson
Journal:  J Neural Transm (Vienna)       Date:  2008-03-20       Impact factor: 3.575

5.  Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: II. behavioural characterisation of RG-15.

Authors:  István Gyertyán; Katalin Sághy; Judit Laszy; Ottilia Elekes; Rita Kedves; Larisza I Gémesi; Gabriella Pásztor; Mária Zájer-Balázs; Margit Kapás; Eva Agai Csongor; György Domány; Béla Kiss; Zsolt Szombathelyi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-06-12       Impact factor: 3.000

6.  Reduction of cocaine self-administration and D3 receptor-mediated behavior by two novel dopamine D3 receptor-selective partial agonists, OS-3-106 and WW-III-55.

Authors:  Timothy H C Cheung; Amy L Loriaux; Suzanne M Weber; Kayla N Chandler; Jeffrey D Lenz; Romina F Schaan; Robert H Mach; Robert R Luedtke; Janet L Neisewander
Journal:  J Pharmacol Exp Ther       Date:  2013-09-09       Impact factor: 4.030

7.  Dopamine stimulation of postnatal murine subventricular zone neurogenesis via the D3 receptor.

Authors:  Yongsoo Kim; Wei-Zhi Wang; Isabelle Comte; Erika Pastrana; Phuong B Tran; Jennifer Brown; Richard J Miller; Fiona Doetsch; Zoltán Molnár; Francis G Szele
Journal:  J Neurochem       Date:  2010-05-06       Impact factor: 5.372

8.  Pharmacological characterization of extracellular acidification rate responses in human D2(long), D3 and D4.4 receptors expressed in Chinese hamster ovary cells.

Authors:  M C Coldwell; I Boyfield; A M Brown; G Stemp; D N Middlemiss
Journal:  Br J Pharmacol       Date:  1999-07       Impact factor: 8.739

9.  Effect of NMDA receptor antagonists on D1, D2 and D1/D2 mediated behaviors in intact rats.

Authors:  R Dall'Olio; R Rimondini; O Gandolfi
Journal:  Psychopharmacology (Berl)       Date:  1996-01       Impact factor: 4.530

10.  Molecular evidence for the functional role of dopamine D3 receptor in the morphine-induced rewarding effect and hyperlocomotion.

Authors:  Minoru Narita; Keisuke Mizuo; Hirokazu Mizoguchi; Mamoru Sakata; Michiko Narita; Leon F Tseng; Tsutomu Suzuki
Journal:  J Neurosci       Date:  2003-02-01       Impact factor: 6.167
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