OBJECTIVE: To compare the tidal volume, minute ventilation, and gas exchange caused by mechanical chest compression with and without mechanical ventilatory support during cardiopulmonary resuscitation (CPR) in a laboratory model of cardiac arrest. DESIGN: A laboratory swine model of CPR was used. Eight animals with and eight animals without mechanical ventilation received chest compression (100/min) for 10 min. Coronary perfusion pressure, tidal volume, and minute ventilation were recorded continuously. INTERVENTIONS: Ventricular fibrillation for 6 min without CPR, then mechanical chest compression for 10 min. RESULTS: During the first minute of chest compression, mean (+/- S.D.) minute ventilation was 11.2 +/- 5.9 l/min in the mechanically ventilated group and 4.5 +/- 2.8 l/min in the group without mechanical ventilation (P = 0.01). Minute ventilation gradually declined to 5.8 +/- 1.4 l/min and 1.7 +/- 1.6 l/min, respectively, during the last minute of chest compression (P < 0.0001). After 10 min of chest compression, mean arterial pH was significantly more acidemic in the group without mechanical ventilation (7.16 +/- 0.13 compared with 7.30 +/- 0.07 units) and PCO2 was higher (62 +/- 19 compared with 35 +/- 9 mmHg). Mixed venous PCO2 was also higher (76 +/- 15 compared with 61 +/- 8 mmHg). CONCLUSION: Standard chest compression alone produced measurable tidal volume and minute ventilation. However, after 10 min of chest compression following 6 min of untreated ventricular fibrillation, it failed to sustain pulmonary gas exchange as indicated by significantly greater arterial and mixed venous hypercarbic acidosis when compared with a group receiving mechanical ventilation.
OBJECTIVE: To compare the tidal volume, minute ventilation, and gas exchange caused by mechanical chest compression with and without mechanical ventilatory support during cardiopulmonary resuscitation (CPR) in a laboratory model of cardiac arrest. DESIGN: A laboratory swine model of CPR was used. Eight animals with and eight animals without mechanical ventilation received chest compression (100/min) for 10 min. Coronary perfusion pressure, tidal volume, and minute ventilation were recorded continuously. INTERVENTIONS:Ventricular fibrillation for 6 min without CPR, then mechanical chest compression for 10 min. RESULTS: During the first minute of chest compression, mean (+/- S.D.) minute ventilation was 11.2 +/- 5.9 l/min in the mechanically ventilated group and 4.5 +/- 2.8 l/min in the group without mechanical ventilation (P = 0.01). Minute ventilation gradually declined to 5.8 +/- 1.4 l/min and 1.7 +/- 1.6 l/min, respectively, during the last minute of chest compression (P < 0.0001). After 10 min of chest compression, mean arterial pH was significantly more acidemic in the group without mechanical ventilation (7.16 +/- 0.13 compared with 7.30 +/- 0.07 units) and PCO2 was higher (62 +/- 19 compared with 35 +/- 9 mmHg). Mixed venous PCO2 was also higher (76 +/- 15 compared with 61 +/- 8 mmHg). CONCLUSION: Standard chest compression alone produced measurable tidal volume and minute ventilation. However, after 10 min of chest compression following 6 min of untreated ventricular fibrillation, it failed to sustain pulmonary gas exchange as indicated by significantly greater arterial and mixed venous hypercarbic acidosis when compared with a group receiving mechanical ventilation.
Authors: Siobhan P Brown; Henry Wang; Tom P Aufderheide; Christian Vaillancourt; Robert H Schmicker; Sheldon Cheskes; Ron Straight; Peter Kudenchuk; Laurie Morrison; M Riccardo Colella; Joseph Condle; George Gamez; David Hostler; Tami Kayea; Sally Ragsdale; Shannon Stephens; Graham Nichol Journal: Am Heart J Date: 2014-11-20 Impact factor: 4.749
Authors: Mary P Chang; Yuanzheng Lu; Brian Leroux; Elisabete Aramendi Ecenarro; Pamela Owens; Henry E Wang; Ahamed H Idris Journal: Resuscitation Date: 2019-05-18 Impact factor: 5.262
Authors: Jose María Iglesias; Jesús López-Herce; Javier Urbano; Maria José Solana; Santiago Mencía; Jimena Del Castillo Journal: Intensive Care Med Date: 2010-02-11 Impact factor: 17.440
Authors: Marta Botran; Jesus Lopez-Herce; Javier Urbano; Maria J Solana; Ana Garcia; Angel Carrillo Journal: Intensive Care Med Date: 2011-08-17 Impact factor: 17.440
Authors: Catherine Bertrand; François Hemery; Pierre Carli; Patrick Goldstein; Catherine Espesson; Michel Rüttimann; Jean Michel Macher; Brigitte Raffy; Patrick Fuster; François Dolveck; Alain Rozenberg; Eric Lecarpentier; Philippe Duvaldestin; Jean-Marie Saissy; Georges Boussignac; Laurent Brochard Journal: Intensive Care Med Date: 2006-04-28 Impact factor: 17.440
Authors: Clemens Kill; Monika Galbas; Christian Neuhaus; Oliver Hahn; Pascal Wallot; Karl Kesper; Hinnerk Wulf; Wolfgang Dersch Journal: PLoS One Date: 2015-05-26 Impact factor: 3.240