Literature DB >> 7843405

Possible involvement of the transcription factor ISGF3 gamma in virus-induced expression of the IFN-beta gene.

T Kawakami1, M Matsumoto, M Sato, H Harada, T Taniguchi, M Kitagawa.   

Abstract

Two virus-inducible transcription factors, IRF-1 and IRF-2 have been identified as an activator and a repressor, respectively, of the type I interferon (IFN) genes. Recent studies with mice carrying null mutations for the IRF-1 or IRF-2 alleles have revealed the existence of IRF-1-dependent and -independent pathways mediating IFN-beta gene induction. Here we report that the expression of an IRF family member ISGF3 gamma is induced upon viral infection in IRF-1-/-, IRF-2-/- embryonic fibroblasts. Furthermore, ISGF3 gamma can bind to a virus-inducible promoter element in the IFN-beta gene. These results suggest that ISGF3 gamma or complex containing ISGF3 gamma is involved in the IRF-1-independent pathway mediating IFN-beta gene regulation.

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Year:  1995        PMID： 7843405     DOI： 10.1016/0014-5793(94)01426-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

1.  The interferon-inducible murine p48 (ISGF3gamma) gene is regulated by protooncogene c-myc.

Authors:  X Weihua; D J Lindner; D V Kalvakolanu
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-08       Impact factor: 11.205

Review 2.  The interferon signaling network and transcription factor C/EBP-beta.

Authors:  Hui Li; Padmaja Gade; Weihua Xiao; Dhan V Kalvakolanu
Journal:  Cell Mol Immunol       Date:  2007-12       Impact factor: 11.530

3.  Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE).

Authors:  T Matsuyama; A Grossman; H W Mittrücker; D P Siderovski; F Kiefer; T Kawakami; C D Richardson; T Taniguchi; S K Yoshinaga; T W Mak
Journal:  Nucleic Acids Res       Date:  1995-06-25       Impact factor: 16.971

4.  Use of differential display reverse transcription-PCR to reveal cellular changes during stimuli that result in herpes simplex virus type 1 reactivation from latency: upregulation of immediate-early cellular response genes TIS7, interferon, and interferon regulatory factor-1.

Authors:  R Tal-Singer; W Podrzucki; T M Lasner; A Skokotas; J J Leary; N W Fraser; S L Berger
Journal:  J Virol       Date:  1998-02       Impact factor: 5.103

5.  Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300.

Authors:  M Yoneyama; W Suhara; Y Fukuhara; M Fukuda; E Nishida; T Fujita
Journal:  EMBO J       Date:  1998-02-16       Impact factor: 11.598

6.  Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation.

Authors:  R Lin; C Heylbroeck; P M Pitha; J Hiscott
Journal:  Mol Cell Biol       Date:  1998-05       Impact factor: 4.272

7.  Disturbance of tumor necrosis factor alpha-mediated beta interferon signaling in cervical carcinoma cells.

Authors:  Anastasia Bachmann; Brigitte Hanke; Rainer Zawatzky; Ubaldo Soto; Jan van Riggelen; Harald zur Hausen; Frank Rösl
Journal:  J Virol       Date:  2002-01       Impact factor: 5.103

8.  Identification of distal silencing elements in the murine interferon-A11 gene promoter.

Authors:  P Roffet; S Lopez; S Navarro; M T Bandu; C Coulombel; M Vignal; J Doly; G Vodjdani
Journal:  Biochem J       Date:  1996-08-01       Impact factor: 3.857

9.  IRF9 Prevents CD8+ T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection.

Authors:  Magdalena Huber; Tamara Suprunenko; Thomas Ashhurst; Felix Marbach; Hartmann Raifer; Svenja Wolff; Thomas Strecker; Barney Viengkhou; So Ri Jung; Hannah-Lena Obermann; Stefan Bauer; Haifeng C Xu; Philipp A Lang; Adomati Tom; Karl S Lang; Nicholas J C King; Iain L Campbell; Markus J Hofer
Journal:  J Virol       Date:  2017-10-27       Impact factor: 5.103

Review 10.  STAT2 and IRF9: Beyond ISGF3.

Authors:  Karin Fink; Nathalie Grandvaux
Journal:  JAKSTAT       Date:  2013-12-18
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