Literature DB >> 24498542

STAT2 and IRF9: Beyond ISGF3.

Karin Fink1, Nathalie Grandvaux1.   

Abstract

Cytokine signaling is mediated by the combinatorial usage of seven STAT proteins that form homo- or heterodimers involved in the regulation of specific transcriptional programs. Among STATs, STAT2 is classically known to dimerize with STAT1 and together with IRF9 forms the ISGF3 transcription factor complex that has long been considered a hallmark of activation by type I and type III interferons. However, accumulating evidence reveal distinct facets of STAT2 and IRF9 activity mediated by the segregation in alternative STAT1-independent complexes/pathways that are thought to trigger different transcriptional programs. The goal of this review is to summarize our current knowledge of the stimuli, regulatory mechanisms, and function of these alternative pathways.

Entities:  

Keywords:  IRF9; ISGF3; ISGs; STAT; TNFα; gene expression; interferon; signaling; synergism

Year:  2013        PMID： 24498542      PMCID： PMC3906322          DOI： 10.4161/jkst.27521

Source DB:  PubMed          Journal:  JAKSTAT        ISSN： 2162-3988


  63 in total

1.  IL-28, IL-29 and their class II cytokine receptor IL-28R.

Authors:  Paul Sheppard; Wayne Kindsvogel; Wenfeng Xu; Katherine Henderson; Stacy Schlutsmeyer; Theodore E Whitmore; Rolf Kuestner; Ursula Garrigues; Carl Birks; Jenny Roraback; Craig Ostrander; Dennis Dong; Jinu Shin; Scott Presnell; Brian Fox; Betty Haldeman; Emily Cooper; David Taft; Teresa Gilbert; Francis J Grant; Monica Tackett; William Krivan; Gary McKnight; Chris Clegg; Don Foster; Kevin M Klucher
Journal:  Nat Immunol       Date:  2002-12-02       Impact factor: 25.606

Review 2.  Mechanisms of type-I- and type-II-interferon-mediated signalling.

Authors:  Leonidas C Platanias
Journal:  Nat Rev Immunol       Date:  2005-05       Impact factor: 53.106

3.  Synergy between interferon-gamma and tumor necrosis factor-alpha in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor kappaB.

Authors:  Y Ohmori; R D Schreiber; T A Hamilton
Journal:  J Biol Chem       Date:  1997-06-06       Impact factor: 5.157

4.  TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein.

Authors:  Deborah L Clarke; Rachel L Clifford; Sarawut Jindarat; David Proud; Linhua Pang; Maria Belvisi; Alan J Knox
Journal:  J Biol Chem       Date:  2010-09-17       Impact factor: 5.157

5.  Differential regulation of interferon regulatory factor (IRF)-7 and IRF-9 gene expression in the central nervous system during viral infection.

Authors:  Shalina S Ousman; Jianping Wang; Iain L Campbell
Journal:  J Virol       Date:  2005-06       Impact factor: 5.103

Review 6.  Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.

Authors:  J E Darnell; I M Kerr; G R Stark
Journal:  Science       Date:  1994-06-03       Impact factor: 47.728

7.  The addition of tumor necrosis factor plus beta interferon induces a novel synergistic antiviral state against poxviruses in primary human fibroblasts.

Authors:  Eric Bartee; Mohamed R Mohamed; M Cecilia Lopez; Henry V Baker; Grant McFadden
Journal:  J Virol       Date:  2008-10-29       Impact factor: 5.103

Review 8.  ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering.

Authors:  Thomas Gaj; Charles A Gersbach; Carlos F Barbas
Journal:  Trends Biotechnol       Date:  2013-05-09       Impact factor: 19.536

9.  Organization of the mouse RNA-specific adenosine deaminase Adar1 gene 5'-region and demonstration of STAT1-independent, STAT2-dependent transcriptional activation by interferon.

Authors:  Cyril X George; Sonali Das; Charles E Samuel
Journal:  Virology       Date:  2008-09-06       Impact factor: 3.616

Review 10.  Interferon-stimulated genes and their antiviral effector functions.

Authors:  John W Schoggins; Charles M Rice
Journal:  Curr Opin Virol       Date:  2011-12       Impact factor: 7.090
View more
  66 in total

1.  Human Papillomavirus 16 E2 Regulates Keratinocyte Gene Expression Relevant to Cancer and the Viral Life Cycle.

Authors:  Michael R Evans; Claire D James; Molly L Bristol; Tara J Nulton; Xu Wang; Namsimar Kaur; Elizabeth A White; Brad Windle; Iain M Morgan
Journal:  J Virol       Date:  2019-02-05       Impact factor: 5.103

2.  Computational Systems Biology of Psoriasis: Are We Ready for the Age of Omics and Systems Biomarkers?

Authors:  Tuba Sevimoglu; Kazim Yalcin Arga
Journal:  OMICS       Date:  2015-10-19

Review 3.  MDA5 and LGP2: accomplices and antagonists of antiviral signal transduction.

Authors:  Kenny R Rodriguez; Annie M Bruns; Curt M Horvath
Journal:  J Virol       Date:  2014-05-21       Impact factor: 5.103

4.  Comprehensive network map of interferon gamma signaling.

Authors:  Mohd Younis Bhat; Hitendra S Solanki; Jayshree Advani; Aafaque Ahmad Khan; T S Keshava Prasad; Harsha Gowda; Saravanan Thiyagarajan; Aditi Chatterjee
Journal:  J Cell Commun Signal       Date:  2018-09-06       Impact factor: 5.782

5.  Detection of Regional Variation in Selection Intensity within Protein-Coding Genes Using DNA Sequence Polymorphism and Divergence.

Authors:  Zi-Ming Zhao; Michael C Campbell; Ning Li; Daniel S W Lee; Zhang Zhang; Jeffrey P Townsend
Journal:  Mol Biol Evol       Date:  2017-11-01       Impact factor: 16.240

6.  Reconstructing the Molecular Function of Genetic Variation in Regulatory Networks.

Authors:  Roni Wilentzik; Chun Jimmie Ye; Irit Gat-Viks
Journal:  Genetics       Date:  2017-10-18       Impact factor: 4.562

7.  Noncanonical Effects of IRF9 in Intestinal Inflammation: More than Type I and Type III Interferons.

Authors:  Isabella Rauch; Felix Rosebrock; Eva Hainzl; Susanne Heider; Andrea Majoros; Sebastian Wienerroither; Birgit Strobl; Silvia Stockinger; Lukas Kenner; Mathias Müller; Thomas Decker
Journal:  Mol Cell Biol       Date:  2015-04-27       Impact factor: 4.272

Review 8.  EZH2 as a mediator of treatment resistance in melanoma.

Authors:  Jessamy C Tiffen; Stuart J Gallagher; Hsin-Yi Tseng; Fabian V Filipp; Barbara Fazekas de St. Groth; Peter Hersey
Journal:  Pigment Cell Melanoma Res       Date:  2016-05-25       Impact factor: 4.693

9.  Regulated IFN signalling preserves the stemness of intestinal stem cells by restricting differentiation into secretory-cell lineages.

Authors:  Taku Sato; Shun Ishikawa; Jumpei Asano; Hirona Yamamoto; Masayuki Fujii; Toshiro Sato; Kouhei Yamamoto; Keisuke Kitagaki; Takumi Akashi; Ryuichi Okamoto; Toshiaki Ohteki
Journal:  Nat Cell Biol       Date:  2020-07-20       Impact factor: 28.824

10.  Distinctive Roles for Type I and Type II Interferons and Interferon Regulatory Factors in the Host Cell Defense against Varicella-Zoster Virus.

Authors:  Nandini Sen; Phillip Sung; Arjun Panda; Ann M Arvin
Journal:  J Virol       Date:  2018-10-12       Impact factor: 5.103
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.