Literature DB >> 7829088

Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development.

C Kraus1, T Liehr, J Hülsken, J Behrens, W Birchmeier, K H Grzeschik, W G Ballhausen.   

Abstract

The human beta-catenin locus (CTNNB1) was mapped by in situ fluorescence analysis to band p21 on the short arm of chromosome 3, a region frequently affected by somatic alterations in a variety of tumors. PCR primers for the genomic amplification of beta-catenin sequences were selected on the basis of homology to exon 4 of the Drosophila armadillo gene. Analysis of a panel of somatic cell hybrids confirmed the localization of beta-catenin on human chromosome 3. Furthermore, exclusion mapping of three hybrids carrying defined fragments of the short arm of human chromosome 3 allowed us to determine the position of the CTNNB1 locus close to the marker D3S2 in 3p21.

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Year:  1994        PMID： 7829088     DOI： 10.1006/geno.1994.1493

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  33 in total

1.  Clinical implications of β-catenin protein expression in breast cancer.

Authors:  Ziyi Wang; Hao Zhang; Jianxin Hou; Jianing Niu; Zhenhai Ma; Haidong Zhao; Caigang Liu
Journal:  Int J Clin Exp Pathol       Date:  2015-11-01

Review 2.  Genetic variations in colorectal cancer risk and clinical outcome.

Authors:  Kejin Zhang; Jesse Civan; Sushmita Mukherjee; Fenil Patel; Hushan Yang
Journal:  World J Gastroenterol       Date:  2014-04-21       Impact factor: 5.742

3.  Characterization of the human beta-catenin gene.

Authors:  A L Norris; A Bailey; J Askham; A Whitehouse; P M Clissold; A F Markham; D M Meredith
Journal:  Mamm Genome       Date:  1996-02       Impact factor: 2.957

4.  Insulin detemir enhances proglucagon gene expression in the intestinal L cells via stimulating β-catenin and CREB activities.

Authors:  Shenghao Liu; Rui Liu; Yu-Ting Chiang; Lifang Song; Xiaoming Li; Tianru Jin; Qinghua Wang
Journal:  Am J Physiol Endocrinol Metab       Date:  2012-07-17       Impact factor: 4.310

5.  A novel coding exon of the human adenomatous polyposis coli gene.

Authors:  Z Suleková; W G Ballhausen
Journal:  Hum Genet       Date:  1995-10       Impact factor: 4.132

6.  The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers.

Authors:  H Aberle; C Bierkamp; D Torchard; O Serova; T Wagner; E Natt; J Wirsching; C Heidkämper; M Montagna; H T Lynch
Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-03       Impact factor: 11.205

7.  Chromosome 3p loss of heterozygosity and mutation analysis of the FHIT and beta-cat genes in squamous cell carcinoma of the head and neck.

Authors:  M V González; M F Pello; P Ablanedo; C Suárez; V Alvarez; E Coto
Journal:  J Clin Pathol       Date:  1998-07       Impact factor: 3.411

8.  Thyroid cancer: current molecular perspectives.

Authors:  Francesca Giusti; Alberto Falchetti; Francesco Franceschelli; Francesca Marini; Annalisa Tanini; Maria Luisa Brandi
Journal:  J Oncol       Date:  2010-03-29       Impact factor: 4.375

9.  Regional localization of rat peripheral myelin protein 22 (Pmp22) gene to chromosome 10q22 by FISH.

Authors:  T Liehr; B Rautenstrauss
Journal:  Mamm Genome       Date:  1995-07       Impact factor: 2.957

10.  Diabetic Retinopathy and Laser Therapy in Rats: A Protein-Protein Interaction Network Analysis.

Authors:  Akram Safaei; Mostafa Rezaei Tavirani; Mona Zamanian Azodi; Alireza Lashay; Seyed Farzad Mohammadi; Mohamad Ghasemi Broumand; Ali Asghar Peyvandi; Farshad Okhovatian; Hassan Peyvandi; Mohammad Rostami Nejad
Journal:  J Lasers Med Sci       Date:  2017-08-29
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