Literature DB >> 26823833

Clinical implications of β-catenin protein expression in breast cancer.

Ziyi Wang1, Hao Zhang1, Jianxin Hou1, Jianing Niu1, Zhenhai Ma1, Haidong Zhao1, Caigang Liu1.   

Abstract

The objective of this study was to examine the expression and significance of β-catenin in the diagnosis and prognosis of breast cancer. Overall, 241 patients with histologically confirmed breast cancer who had undergone radical surgery were enrolled in this study. β-catenin protein expression in breast cancer samples was evaluated by immunohistochemistry. β-catenin was expressed in Nuclei/Plasma of the samples from 41 patients. β-catenin protein expression correlated with the histological grade of the tumor (P<0.05) and Ki-67 labeling (P<0.01). Survival analysis showed that β-catenin expression negatively correlated with breast cancer-specific survival. Our results showed prominent expression of β-catenin in breast cancer and strongly implicate the β-catenin in tumor promotion.

Entities:  

Keywords:  Breast cancer; Ki-67; survival; tumor marker; β-catenin

Mesh：

Substances：

Year:  2015        PMID： 26823833      PMCID： PMC4713619     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


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