Literature DB >> 7816807

Comparative genomic analysis of tumors: detection of DNA losses and amplification.

N A Lisitsyn1, N M Lisitsina, G Dalbagni, P Barker, C A Sanchez, J Gnarra, W M Linehan, B J Reid, M H Wigler.   

Abstract

We demonstrate the use of representational difference analysis for cloning probes that detect DNA loss and amplification in tumors. Using DNA isolated from human tumor cell lines to drive hybridization against matched normal DNA, we were able to identify six genomic regions that are homozygously deleted in cultured cancer cells. When this method was applied in the reverse way, using normal DNA to drive hybridization against tumor cell DNA, we readily isolated probes detecting amplification. Representational difference analysis was also performed on DNAs derived from tumor biopsies, and we thereby discovered a probe detecting very frequent homozygous loss in colon cancer cell lines and located on chromosome 3p.

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Year:  1995        PMID： 7816807      PMCID： PMC42835          DOI： 10.1073/pnas.92.1.151

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  9 in total

Review 1.  Loss of constitutional heterozygosity in human cancer.

Authors:  D Lasko; W Cavenee; M Nordenskjöld
Journal:  Annu Rev Genet       Date:  1991       Impact factor: 16.830

2.  17p allelic deletions and p53 protein overexpression in Barrett's adenocarcinoma.

Authors:  P L Blount; S Ramel; W H Raskind; R C Haggitt; C A Sanchez; P J Dean; P S Rabinovitch; B J Reid
Journal:  Cancer Res       Date:  1991-10-15       Impact factor: 12.701

3.  Histopathological, cytogenetic, and molecular characterization of renal cortical tumors.

Authors:  J C Presti; P H Rao; Q Chen; V E Reuter; F P Li; W R Fair; S C Jhanwar
Journal:  Cancer Res       Date:  1991-03-01       Impact factor: 12.701

4.  Cloning the differences between two complex genomes.

Authors:  N Lisitsyn; N Lisitsyn; M Wigler
Journal:  Science       Date:  1993-02-12       Impact factor: 47.728

5.  Direct isolation of polymorphic markers linked to a trait by genetically directed representational difference analysis.

Authors:  N A Lisitsyn; J A Segre; K Kusumi; N M Lisitsyn; J H Nadeau; W N Frankel; M H Wigler; E S Lander
Journal:  Nat Genet       Date:  1994-01       Impact factor: 38.330

Review 6.  Chromosome aberrations and cancer.

Authors:  E Solomon; J Borrow; A D Goddard
Journal:  Science       Date:  1991-11-22       Impact factor: 47.728

7.  Cell culture of human colon adenomas and carcinomas.

Authors:  J K Willson; G N Bittner; T D Oberley; L F Meisner; J L Weese
Journal:  Cancer Res       Date:  1987-05-15       Impact factor: 12.701

Review 8.  Amplification of cellular oncogenes: a predictor of clinical outcome in human cancer.

Authors:  M Schwab; L C Amler
Journal:  Genes Chromosomes Cancer       Date:  1990-01       Impact factor: 5.006

9.  Molecular and cellular characterization of human renal cell carcinoma cell lines.

Authors:  P Anglard; E Trahan; S Liu; F Latif; M J Merino; M I Lerman; B Zbar; W M Linehan
Journal:  Cancer Res       Date:  1992-01-15       Impact factor: 12.701
  9 in total
  20 in total

1.  Tumor suppressors on 3p: a neoclassic quartet.

Authors:  K Huebner
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-18       Impact factor: 11.205

Review 2.  Molecular genetics of ovarian cancer.

Authors:  A N Shelling; W Foulkes
Journal:  Mol Biotechnol       Date:  2001-09       Impact factor: 2.695

Review 3.  Early events during neoplastic progression in Barrett's esophagus.

Authors:  Brian J Reid
Journal:  Cancer Biomark       Date:  2010       Impact factor: 4.388

4.  Deletion at fragile sites is a common and early event in Barrett's esophagus.

Authors:  Lisa A Lai; Rumen Kostadinov; Michael T Barrett; Daniel A Peiffer; Dimitry Pokholok; Robert Odze; Carissa A Sanchez; Carlo C Maley; Brian J Reid; Kevin L Gunderson; Peter S Rabinovitch
Journal:  Mol Cancer Res       Date:  2010-07-20       Impact factor: 5.852

5.  P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase.

Authors:  M P Myers; J P Stolarov; C Eng; J Li; S I Wang; M H Wigler; R Parsons; N K Tonks
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-19       Impact factor: 11.205

6.  Representational difference analysis using minute quantities of DNA.

Authors:  L Michiels; F Van Leuven; J J van den Oord; C De Wolf-Peeters; J Delabie
Journal:  Nucleic Acids Res       Date:  1998-08-01       Impact factor: 16.971

Review 7.  Differential display of mRNA.

Authors:  J S Zhang; E L Duncan; A C Chang; R R Reddel
Journal:  Mol Biotechnol       Date:  1998-10       Impact factor: 2.695

8.  A simplified genomic subtractive procedure for isolating deleted sequences.

Authors:  P Hou; Z H Wang; X Q Wang; M Wu
Journal:  Nucleic Acids Res       Date:  1996-06-01       Impact factor: 16.971

9.  Identification by representational difference analysis of a homozygous deletion in pancreatic carcinoma that lies within the BRCA2 region.

Authors:  M Schutte; L T da Costa; S A Hahn; C Moskaluk; A T Hoque; E Rozenblum; C L Weinstein; M Bittner; P S Meltzer; J M Trent
Journal:  Proc Natl Acad Sci U S A       Date:  1995-06-20       Impact factor: 11.205

10.  Molecular karyotype (amplotype) of metastatic colorectal cancer by unbiased arbitrarily primed PCR DNA fingerprinting.

Authors:  S Malkhosyan; J Yasuda; J L Soto; T Sekiya; J Yokota; M Perucho
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-18       Impact factor: 11.205
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