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Literature DB >> 7811325

An arcane role of DNA in transcription activation.

Abstract

The mechanism by which the cAMP receptor protein (CRP) activates transcription has been investigated using the lac promoter of Escherichia coli. For transcription activation, an interaction between DNA-bound CRP and RNA polymerase is not sufficient. CRP must bind to a site in the same DNA and close to the promoter. CRP action requires an intact spacer DNA to provide a rigid support in building a CRP-RNA polymerase protein bridge or to allow a conformational change in the DNA to be transmitted to the lac promoter using the protein bridge as a structural support.

Entities: Gene Species

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Year: 1994 PMID： 7811325 PMCID： PMC44650 DOI： 10.1073/pnas.91.18.8582

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

35 in total

1. Genetic regulation: the Lac control region.

Authors: R C Dickson; J Abelson; W M Barnes; W S Reznikoff
Journal: Science Date: 1975-01-10 Impact factor: 47.728

2. Monoclonal antibodies that inhibit activation of transcription by the Escherichia coli cyclic AMP receptor protein.

Authors: X M Li; J S Krakow
Journal: J Biol Chem Date: 1988-03-05 Impact factor: 5.157

3. RNA polymerase-DNA complexes. I. The study of the conformation of nucleic acids at the growing point of RNA in an RNA polymerase-DNA system.

Authors: R S Beabealashvily; V I Ivanov; L E Minchenkova; L P Savotchkina
Journal: Biochim Biophys Acta Date: 1972-01-18

4. Helix formation by d(TA) oligomers. 3. Electrostatic effects.

Authors: E L Elson; I E Scheffler; R L Baldwin
Journal: J Mol Biol Date: 1970-12-28 Impact factor: 5.469

5. Cooperative binding of lambda repressors to sites separated by integral turns of the DNA helix.

Authors: A Hochschild; M Ptashne
Journal: Cell Date: 1986-03-14 Impact factor: 41.582

6. Mechanism of CRP-cAMP activation of lac operon transcription initiation activation of the P1 promoter.

Authors: T P Malan; A Kolb; H Buc; W R McClure
Journal: J Mol Biol Date: 1984-12-25 Impact factor: 5.469

7. Catenation and supercoiling in the products of bacteriophage lambda integrative recombination in vitro.

Authors: K Mizuuchi; M Gellert; R A Weisberg; H A Nash
Journal: J Mol Biol Date: 1980-08-25 Impact factor: 5.469

8. Transmission of stability (telestability) in deoxyribonucleic acid. Physical and enzymatic studies on the duplex block polymer d(C15A15) - d(T15G15).

Authors: J F Burd; R M Wartell; J B Dodgson; R D Wells
Journal: J Biol Chem Date: 1975-07-10 Impact factor: 5.157

An arcane role of DNA in transcription activation.

1. Genetic regulation: the Lac control region.

2. Monoclonal antibodies that inhibit activation of transcription by the Escherichia coli cyclic AMP receptor protein.

3. RNA polymerase-DNA complexes. I. The study of the conformation of nucleic acids at the growing point of RNA in an RNA polymerase-DNA system.

4. Helix formation by d(TA) oligomers. 3. Electrostatic effects.

5. Cooperative binding of lambda repressors to sites separated by integral turns of the DNA helix.

6. Mechanism of CRP-cAMP activation of lac operon transcription initiation activation of the P1 promoter.

7. Catenation and supercoiling in the products of bacteriophage lambda integrative recombination in vitro.

8. Transmission of stability (telestability) in deoxyribonucleic acid. Physical and enzymatic studies on the duplex block polymer d(C15A15) - d(T15G15).

9. Cooperative transitions in DNA with no separation of strands.

10. Interactions between DNA-bound repressors govern regulation by the lambda phage repressor.

1. Analysis of the spacer DNA between the cyclic AMP receptor protein binding site and the lac promoter.

2. Distortion in the spacer region of Pm during activation of middle transcription of phage Mu.

3. Influence of DNA geometry on transcriptional activation in Escherichia coli.

4. The -45 region of the Escherichia coli lac promoter: CAP-dependent and CAP-independent transcription.

5. Repression and activation of transcription by Gal and Lac repressors: involvement of alpha subunit of RNA polymerase.