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Literature DB >> 1088926

Genetic regulation: the Lac control region.

R C Dickson, J Abelson, W M Barnes, W S Reznikoff.

Abstract

The nucleotide sequence of the lac promoter-operator region has been determined. The 122 base pairs comprising this region include the recognition sites for RNA polymerase, the positive regulatory protein, CAP, and the negative regulatory protein, the repressor. Identification of mutant variants of the sequence combined with the in vitro biochemical studies of others has allowed us to tentatively identify the recognition site for each of these proteins, and to suggest how CAP might act at a distance to affect the interaction of RNA polymerase with the promoter.

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Year: 1975 PMID： 1088926 DOI： 10.1126/science.1088926

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

148 in total

1. Noise-based switches and amplifiers for gene expression.

Authors: J Hasty; J Pradines; M Dolnik; J J Collins
Journal: Proc Natl Acad Sci U S A Date: 2000-02-29 Impact factor: 11.205

2. Nucleotide sequence of an RNA polymerase binding site at an early T7 promoter.

Authors: D Pribnow
Journal: Proc Natl Acad Sci U S A Date: 1975-03 Impact factor: 11.205

3. Role of the RNA polymerase alpha subunits in MetR-dependent activation of metE and metH: important residues in the C-terminal domain and orientation requirements within RNA polymerase.

Authors: P S Fritsch; M L Urbanowski; G V Stauffer
Journal: J Bacteriol Date: 2000-10 Impact factor: 3.490

4. Reverse engineering gene networks: integrating genetic perturbations with dynamical modeling.

Authors: Jesper Tegner; M K Stephen Yeung; Jeff Hasty; James J Collins
Journal: Proc Natl Acad Sci U S A Date: 2003-05-01 Impact factor: 11.205

Review 5. Catabolite gene activator protein activation of lac transcription.

Authors: W S Reznikoff
Journal: J Bacteriol Date: 1992-02 Impact factor: 3.490

6. Cloning and nucleotide sequences of the Bacillus stearothermophilus neutral protease gene and its transcriptional activator gene.

Authors: Y Nishiya; T Imanaka
Journal: J Bacteriol Date: 1990-09 Impact factor: 3.490

Genetic regulation: the Lac control region.

1. Noise-based switches and amplifiers for gene expression.

2. Nucleotide sequence of an RNA polymerase binding site at an early T7 promoter.

3. Role of the RNA polymerase alpha subunits in MetR-dependent activation of metE and metH: important residues in the C-terminal domain and orientation requirements within RNA polymerase.

4. Reverse engineering gene networks: integrating genetic perturbations with dynamical modeling.

Review 5. Catabolite gene activator protein activation of lac transcription.

6. Cloning and nucleotide sequences of the Bacillus stearothermophilus neutral protease gene and its transcriptional activator gene.

7. NMR study of the structural changes induced in the E. coli lac promoter by the specific binding of the CAP protein.

8. Preparative fractionation of DNA restriction fragments by reversed phase column chromatography.

9. Regulatory region of the divergent Klebsiella pneumoniae lac operon.

10. Nucleotide sequence of the operator-promoter region of the galactose operon of Escherichia coli.