Literature DB >> 7811040

Substrate specificity of Epstein-Barr virus thymidine kinase.

P P Tung1, W C Summers.   

Abstract

Purified recombinant protein encoded by the BXLF-I open reading frame of the Epstein-Barr virus genome has thymidine kinase activity. The substrate behaviors of various nucleosides toward this enzyme were tested. Halogenated deoxyuridines, zidovudine, and bromovinyldeoxyuridine are efficient substrates, while acyclovir and dihydroxypropylmethylguanine are relatively poor substrates for the Epstein-Barr virus thymidine kinase.

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Year:  1994        PMID： 7811040      PMCID： PMC284705          DOI： 10.1128/AAC.38.9.2175

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  25 in total

1.  Kinetic studies of herpes simplex virus type 1-encoded thymidine and thymidylate kinase, a multifunctional enzyme.

Authors:  M S Chen; J Walker; W H Prusoff
Journal:  J Biol Chem       Date:  1979-11-10       Impact factor: 5.157

2.  An assay for pyrimidine deoxyribonucleoside kinase using gamma-32P-labeled ATP.

Authors:  M J Dobersen; S Greer
Journal:  Anal Biochem       Date:  1975-08       Impact factor: 3.365

3.  Possible peptide chain termination mutants in thymide kinase gene of a mammalian virus, herpes simplex virus.

Authors:  W P Summers; M Wagner; W C Summers
Journal:  Proc Natl Acad Sci U S A       Date:  1975-10       Impact factor: 11.205

4.  Epstein-Barr virus induces a unique pyrimidine deoxynucleoside kinase activity in superinfected and virus-producer B cell lines.

Authors:  T Stinchcombe; W Clough
Journal:  Biochemistry       Date:  1985-04-09       Impact factor: 3.162

5.  DNA sequence and expression of the B95-8 Epstein-Barr virus genome.

Authors:  R Baer; A T Bankier; M D Biggin; P L Deininger; P J Farrell; T J Gibson; G Hatfull; G S Hudson; S C Satchwell; C Séguin
Journal:  Nature       Date:  1984 Jul 19-25       Impact factor: 49.962

6.  Differential activity of potential antiviral nucleoside analogs on herpes simplex virus-induced and human cellular thymidine kinases.

Authors:  Y C Cheng; G Dutschman; J J Fox; K A Watanabe; H Machida
Journal:  Antimicrob Agents Chemother       Date:  1981-09       Impact factor: 5.191

7.  Thermodynamic studies of the formation and ionization of the magnesium(II) complexes of ADP and ATP over the pH range 5 to 9.

Authors:  R C Phillips; P George; R J Rutman
Journal:  J Am Chem Soc       Date:  1966-06-20       Impact factor: 15.419

8.  Intracellular metabolism and enzymatic phosphorylation of 9-(1,3-dihydroxy-2-propoxymethyl)guanine and acyclovir in herpes simplex virus-infected and uninfected cells.

Authors:  D F Smee; R Boehme; M Chernow; B P Binko; T R Matthews
Journal:  Biochem Pharmacol       Date:  1985-04-01       Impact factor: 5.858

9.  Deoxythymidine kinase induced in the HELA TK- cells by herpes simplex virus type I and type II. Substrate specificity and kinetic behavior.

Authors:  Y C Cheng
Journal:  Biochim Biophys Acta       Date:  1976-12-08

10.  A method for selection of mutations at the tdk locus in Escherichia coli.

Authors:  W C Summers; P Raksin
Journal:  J Bacteriol       Date:  1993-09       Impact factor: 3.490
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  14 in total

1.  Human herpesvirus 8 open reading frame 21 is a thymidine and thymidylate kinase of narrow substrate specificity that efficiently phosphorylates zidovudine but not ganciclovir.

Authors:  E A Gustafson; R F Schinazi; J D Fingeroth
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

2.  Functional divergence of Kaposi's sarcoma-associated herpesvirus and related gamma-2 herpesvirus thymidine kinases: novel cytoplasmic phosphoproteins that alter cellular morphology and disrupt adhesion.

Authors:  Michael B Gill; Jo-Ellen Murphy; Joyce D Fingeroth
Journal:  J Virol       Date:  2005-12       Impact factor: 5.103

3.  Epstein-Barr virus thymidine kinase is a centrosomal resident precisely localized to the periphery of centrioles.

Authors:  Michael B Gill; Jeffery L Kutok; Joyce D Fingeroth
Journal:  J Virol       Date:  2007-04-11       Impact factor: 5.103

4.  Spectrum of activity and mechanisms of resistance of various nucleoside derivatives against gammaherpesviruses.

Authors:  Natacha Coen; Sophie Duraffour; Dimitri Topalis; Robert Snoeck; Graciela Andrei
Journal:  Antimicrob Agents Chemother       Date:  2014-09-29       Impact factor: 5.191

5.  Induction of Epstein-Barr virus kinases to sensitize tumor cells to nucleoside analogues.

Authors:  S M Moore; J S Cannon; Y C Tanhehco; F M Hamzeh; R F Ambinder
Journal:  Antimicrob Agents Chemother       Date:  2001-07       Impact factor: 5.191

6.  Valganciclovir for the Suppression of Epstein-Barr Virus Replication.

Authors:  Jessica E Yager; Amalia S Magaret; Steven R Kuntz; Stacy Selke; Meei-Li Huang; Lawrence Corey; Corey Casper; Anna Wald
Journal:  J Infect Dis       Date:  2017-07-15       Impact factor: 5.226

7.  The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral production.

Authors:  Qiao Meng; Stacy R Hagemeier; Joyce D Fingeroth; Edward Gershburg; Joseph S Pagano; Shannon C Kenney
Journal:  J Virol       Date:  2010-02-24       Impact factor: 5.103

8.  The Epstein-Barr virus thymidine kinase does not phosphorylate ganciclovir or acyclovir and demonstrates a narrow substrate specificity compared to the herpes simplex virus type 1 thymidine kinase.

Authors:  E A Gustafson; A C Chillemi; D R Sage; J D Fingeroth
Journal:  Antimicrob Agents Chemother       Date:  1998-11       Impact factor: 5.191

9.  Activity and mechanism of action of HDVD, a novel pyrimidine nucleoside derivative with high levels of selectivity and potency against gammaherpesviruses.

Authors:  N Coen; U Singh; V Vuyyuru; J J Van den Oord; J Balzarini; S Duraffour; R Snoeck; Y C Cheng; C K Chu; G Andrei
Journal:  J Virol       Date:  2013-01-23       Impact factor: 5.103

10.  Reactivation of thymidine kinase-defective herpes simplex virus is enhanced by nucleoside.

Authors:  R B Tenser; A Gaydos; K A Hay
Journal:  J Virol       Date:  1996-02       Impact factor: 5.103
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