Literature DB >> 2990549

Epstein-Barr virus induces a unique pyrimidine deoxynucleoside kinase activity in superinfected and virus-producer B cell lines.

T Stinchcombe, W Clough.   

Abstract

Epstein-Barr (EB) virus induces a new pyrimidine deoxynucleoside kinase [thymidine kinase (dTk)] activity in Raji B lymphocyte cells after superinfection. This dTk activity is also present in small amounts in the HR-1 virus-producer cell line and in larger amounts in the B95-8 virus-producer line. The dTk activity induced by EB virus coelutes from DEAE-cellulose columns with deoxycytidine kinase (dCk) activity and elutes as a broad peak well separated from the large peaks of cellular dTk and dCk activities. This EB virus-induced pyrimidine deoxynucleoside kinase activity from HR-1 cells differs from cellular kinases in most basic biochemical properties but shares certain properties with the herpes simplex virus dTk.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2990549     DOI： 10.1021/bi00329a034

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  9 in total

1.  A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus-associated lymphoid malignancies.

Authors:  Susan P Perrine; Olivier Hermine; Trudy Small; Felipe Suarez; Richard O'Reilly; Farid Boulad; Joyce Fingeroth; Melissa Askin; Arthur Levy; Steven J Mentzer; Massimo Di Nicola; Alessandro M Gianni; Christoph Klein; Steven Horwitz; Douglas V Faller
Journal:  Blood       Date:  2006-11-21       Impact factor: 22.113

2.  Characterization of the Epstein-Barr virus-encoded thymidine kinase expressed in heterologous eucaryotic and procaryotic systems.

Authors:  E Littler; J R Arrand
Journal:  J Virol       Date:  1988-10       Impact factor: 5.103

3.  Characterization of an Epstein-Barr virus-induced thymidine kinase.

Authors:  M de Turenne-Tessier; T Ooka; G de The; J Daillie
Journal:  J Virol       Date:  1986-03       Impact factor: 5.103

4.  Substrate specificity of Epstein-Barr virus thymidine kinase.

Authors:  P P Tung; W C Summers
Journal:  Antimicrob Agents Chemother       Date:  1994-09       Impact factor: 5.191

5.  Metabolic activation of 9([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human lymphoblastoid cell lines infected with Epstein-Barr virus.

Authors:  J C Lin; D J Nelson; C U Lambe; E I Choi
Journal:  J Virol       Date:  1986-11       Impact factor: 5.103

6.  Differential effects of acyclovir and 9-(1,3-dihydroxy-2-propoxymethyl)guanine on herpes simplex virus and Epstein-Barr virus in a dually infected human lymphoblastoid cell line.

Authors:  C M van der Horst; J C Lin; N Raab-Traub; M C Smith; J S Pagano
Journal:  J Virol       Date:  1987-02       Impact factor: 5.103

7.  Anti-Epstein-Barr virus (EBV) activity of beta-L-5-iododioxolane uracil is dependent on EBV thymidine kinase.

Authors:  T Kira; S P Grill; G E Dutschman; J S Lin; F Qu; Y Choi; C K Chu; Y C Cheng
Journal:  Antimicrob Agents Chemother       Date:  2000-12       Impact factor: 5.191

8.  The Epstein-Barr virus thymidine kinase does not phosphorylate ganciclovir or acyclovir and demonstrates a narrow substrate specificity compared to the herpes simplex virus type 1 thymidine kinase.

Authors:  E A Gustafson; A C Chillemi; D R Sage; J D Fingeroth
Journal:  Antimicrob Agents Chemother       Date:  1998-11       Impact factor: 5.191

9.  Identification of an Epstein-Barr virus-coded thymidine kinase.

Authors:  E Littler; J Zeuthen; A A McBride; E Trøst Sørensen; K L Powell; J E Walsh-Arrand; J R Arrand
Journal:  EMBO J       Date:  1986-08       Impact factor: 11.598
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.