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Literature DB >> 7809153

A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis.

Abstract

The Na+,K(+)-ATPase alpha subunit has three known isoforms, alpha 1, alpha 2 and alpha 3, each encoded by a separate gene. This study was undertaken to determine the functional status of a fourth human alpha-like gene, ATP1AL2. Partial genomic sequence analysis revealed regions exhibiting sequence similarity with exons 3-6 of the Na+,K(+)-ATPase alpha isoform genes. ATP1AL2 cDNAs spanning the coding sequence of a novel P-type ATPase alpha subunit were isolated from a rat testis library. The predicted polypeptide is 1028 amino acids long and exhibits 76-78% identity with the rat Na+,K(+)-ATPase alpha 1, alpha 2 and alpha 3 isoforms, indicating that ATP1AL2 may encode a fourth Na+,K(+)-ATPase alpha isoform. A 3.9-kb mRNA is expressed abundantly in human and rat testis.

Entities: Gene Species

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Year: 1994 PMID： 7809153 PMCID： PMC45558 DOI： 10.1073/pnas.91.26.12952

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

31 in total

1. Expression of Na,K-ATPase isoforms in human heart.

Authors: O I Shamraj; D Melvin; J B Lingrel
Journal: Biochem Biophys Res Commun Date: 1991-09-30 Impact factor: 3.575

2. The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase.

Authors: N N Modyanov; K E Petrukhin; V E Sverdlov; A V Grishin; M Y Orlova; M B Kostina; O I Makarevich; N E Broude; G S Monastyrskaya; E D Sverdlov
Journal: FEBS Lett Date: 1991-01-14 Impact factor: 4.124

3. Structure of the human gastric H,K-ATPase gene and comparison of the 5'-flanking sequences of the human and rat genes.

Authors: P R Newman; J Greeb; T P Keeton; A A Reyes; G E Shull
Journal: DNA Cell Biol Date: 1990-12 Impact factor: 3.311

4. Point mutations in AAUAAA and the poly (A) addition site: effects on the accuracy and efficiency of cleavage and polyadenylation in vitro.

Authors: M D Sheets; S C Ogg; M P Wickens
Journal: Nucleic Acids Res Date: 1990-10-11 Impact factor: 16.971

Review 5. Structure-function relationships of cation binding in the Na+/K(+)-ATPase.

Authors: L A Vasilets; W Schwarz
Journal: Biochim Biophys Acta Date: 1993-10-29

6. A catalogue of splice junction sequences.

Authors: S M Mount
Journal: Nucleic Acids Res Date: 1982-01-22 Impact factor: 16.971

7. Lysine 480 is an essential residue in the putative ATP site of lamb kidney (Na,K)-ATPase. Identification of the pyridoxal 5'-diphospho-5'-adenosine and pyridoxal phosphate reactive residue.

Authors: H R Hinz; T L Kirley
Journal: J Biol Chem Date: 1990-06-25 Impact factor: 5.157

8. Isolation and characterization of a cDNA encoding the putative distal colon H+,K(+)-ATPase. Similarity of deduced amino acid sequence to gastric H+,K(+)-ATPase and Na+,K(+)-ATPase and mRNA expression in distal colon, kidney, and uterus.

Authors: M S Crowson; G E Shull
Journal: J Biol Chem Date: 1992-07-05 Impact factor: 5.157

9. Location of Asn831 of the alpha chain of Na/K-ATPase at the cytoplasmic surface. Implication for topological models.

Authors: S J Karlish; R Goldshleger; P L Jørgensen
Journal: J Biol Chem Date: 1993-02-15 Impact factor: 5.157

10. Immunoferritin determination of the distribution of (Na+ + K+) ATPase over the plasma membranes of renal convoluted tubules. I. Distal segment.

Authors: J Kyte
Journal: J Cell Biol Date: 1976-02 Impact factor: 10.539

58 in total

A putative fourth Na+,K(+)-ATPase alpha-subunit gene is expressed in testis.

1. Expression of Na,K-ATPase isoforms in human heart.

2. The family of human Na,K-ATPase genes. ATP1AL1 gene is transcriptionally competent and probably encodes the related ion transport ATPase.

3. Structure of the human gastric H,K-ATPase gene and comparison of the 5'-flanking sequences of the human and rat genes.

4. Point mutations in AAUAAA and the poly (A) addition site: effects on the accuracy and efficiency of cleavage and polyadenylation in vitro.

Review 5. Structure-function relationships of cation binding in the Na+/K(+)-ATPase.

6. A catalogue of splice junction sequences.

7. Lysine 480 is an essential residue in the putative ATP site of lamb kidney (Na,K)-ATPase. Identification of the pyridoxal 5'-diphospho-5'-adenosine and pyridoxal phosphate reactive residue.

8. Isolation and characterization of a cDNA encoding the putative distal colon H+,K(+)-ATPase. Similarity of deduced amino acid sequence to gastric H+,K(+)-ATPase and Na+,K(+)-ATPase and mRNA expression in distal colon, kidney, and uterus.

9. Location of Asn831 of the alpha chain of Na/K-ATPase at the cytoplasmic surface. Implication for topological models.

10. Immunoferritin determination of the distribution of (Na+ + K+) ATPase over the plasma membranes of renal convoluted tubules. I. Distal segment.

1. Interaction of the alpha subunit of Na,K-ATPase with cofilin.

2. Na,K-ATPase beta-subunit is required for epithelial polarization, suppression of invasion, and cell motility.

Review 3. Endogenous digitalis-like Na+, K+-ATPase inhibitors, and brain function.

4. Partitioning of tissue expression accompanies multiple duplications of the Na+/K+ ATPase alpha subunit gene.

5. Developmental changes in erythrocyte Na(+),K(+)-ATPase subunit abundance and enzyme activity in neonates.

6. K+-induced hyperpolarization in rat mesenteric artery: identification, localization and role of Na+/K+-ATPases.

7. Intense exercise up-regulates Na+,K+-ATPase isoform mRNA, but not protein expression in human skeletal muscle.

8. Na,K-ATPase beta1-subunit increases the translation efficiency of the alpha1-subunit in MSV-MDCK cells.

Review 9. A structural overview of the plasma membrane Na+,K+-ATPase and H+-ATPase ion pumps.

10. Na,K-ATPase alpha4 isoform is essential for sperm fertility.