| Literature DB >> 7809132 |
Abstract
We present considerable data supporting the hypothesis that a Sulfolobus- or Mycoplasma-like endosymbiont, rather than an alpha-proteobacterium, is the ancestor of animal mitochondrial genomes. This hypothesis is based on pronounced similarities in oligonucleotide relative abundance extremes common to animal mtDNA, Sulfolobus, and Mycoplasma capricolum and pronounced discrepancies of these relative abundance values with respect to alpha-proteobacteria. In addition, genomic dinucleotide relative abundance measures place Sulfolobus and M. capricolum among the closest to animal mitochondrial genomes, whereas the classical eubacteria, especially the alpha-proteobacteria, are at excessive distances. There are also considerable molecular and cellular phenotypic analogies among mtDNA, Sulfolobus, and M. capricolum.Entities:
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Year: 1994 PMID: 7809132 PMCID: PMC45536 DOI: 10.1073/pnas.91.26.12842
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN: 0027-8424 Impact factor: 11.205