Literature DB >> 7807534

Synonymous substitutions are clustered in enterobacterial genes.

A Eyre-Walker1.   

Abstract

The spatial distribution of synonymous substitutions in enterobacterial genes is investigated. It is shown that synonymous substitutions are significantly clustered in such a way that a synonymous substitution in one codon elevates the rate of synonymous substitution in an adjacent codon by about 10%. The level of clustering does not appear to be related to the level of gene expression, and it is restricted to a range of two or three codons. There are at least three possible explanations: (1) sequence-directed mutagenesis, (2) recombination, and (3) selection.

Mesh：

Year:  1994        PMID： 7807534     DOI： 10.1007/bf00173413

Source DB:  PubMed          Journal:  J Mol Evol        ISSN： 0022-2844            Impact factor:   2.395


  16 in total

1.  Chromosomal location and evolutionary rate variation in enterobacterial genes.

Authors:  P M Sharp; D C Shields; K H Wolfe; W H Li
Journal:  Science       Date:  1989-11-10       Impact factor: 47.728

2.  Sequence-directed mutagenesis: evidence from a phylogenetic history of human alpha-interferon genes.

Authors:  G B Golding; B W Glickman
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

3.  The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications.

Authors:  P M Sharp; W H Li
Journal:  Nucleic Acids Res       Date:  1987-02-11       Impact factor: 16.971

4.  The rate of synonymous substitution in enterobacterial genes is inversely related to codon usage bias.

Authors:  P M Sharp; W H Li
Journal:  Mol Biol Evol       Date:  1987-05       Impact factor: 16.240

5.  How clonal are bacteria?

Authors:  J M Smith; N H Smith; M O'Rourke; B G Spratt
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-15       Impact factor: 11.205

6.  A comprehensive set of sequence analysis programs for the VAX.

Authors:  J Devereux; P Haeberli; O Smithies
Journal:  Nucleic Acids Res       Date:  1984-01-11       Impact factor: 16.971

7.  Codon usage in bacteria: correlation with gene expressivity.

Authors:  M Gouy; C Gautier
Journal:  Nucleic Acids Res       Date:  1982-11-25       Impact factor: 16.971

8.  Multiple base-pair mutations in yeast.

Authors:  D M Hampsey; J F Ernst; J W Stewart; F Sherman
Journal:  J Mol Biol       Date:  1988-06-05       Impact factor: 5.469

9.  Reduced synonymous substitution rate at the start of enterobacterial genes.

Authors:  A Eyre-Walker; M Bulmer
Journal:  Nucleic Acids Res       Date:  1993-09-25       Impact factor: 16.971

Review 10.  Determinants of DNA sequence divergence between Escherichia coli and Salmonella typhimurium: codon usage, map position, and concerted evolution.

Authors:  P M Sharp
Journal:  J Mol Evol       Date:  1991-07       Impact factor: 2.395
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  3 in total

1.  Methods for the detection of non-random base substitution in virus genes: models of synonymous nucleotide substitution in picornavirus genes.

Authors:  D Haydon; N Knowles; J McCauley
Journal:  Virus Genes       Date:  1998       Impact factor: 2.332

2.  Synonymous substitutions in the Xdh gene of Drosophila: heterogeneous distribution along the coding region.

Authors:  J M Comeron; M Aguadé
Journal:  Genetics       Date:  1996-11       Impact factor: 4.562

3.  Synonymous Genetic Variation in Natural Isolates of Escherichia coli Does Not Predict Where Synonymous Substitutions Occur in a Long-Term Experiment.

Authors:  Rohan Maddamsetti; Philip J Hatcher; Stéphane Cruveiller; Claudine Médigue; Jeffrey E Barrick; Richard E Lenski
Journal:  Mol Biol Evol       Date:  2015-07-20       Impact factor: 16.240
  3 in total

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