Literature DB >> 7768874

The major role of Spo0A in genetic competence is to downregulate abrB, an essential competence gene.

J Hahn1, M Roggiani, D Dubnau.   

Abstract

We show that the major role for Spo0A in the development of genetic competence is to downregulate expression of abrB. AbrB is both a negative regulator and a positive regulator of competence. The negative effects are exerted at multiple points in competence regulation. A regulatory mechanism that is independent of mecA and abrB operates on comK expression.

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Year:  1995        PMID： 7768874      PMCID： PMC177070          DOI： 10.1128/jb.177.12.3601-3605.1995

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  31 in total

1.  Growth medium-independent genetic competence mutants of Bacillus subtilis.

Authors:  D Dubnau; M Roggiani
Journal:  J Bacteriol       Date:  1990-07       Impact factor: 3.490

2.  REQUIREMENTS FOR TRANSFORMATION IN BACILLUS SUBTILIS.

Authors:  C Anagnostopoulos; J Spizizen
Journal:  J Bacteriol       Date:  1961-05       Impact factor: 3.490

3.  Growth stage signal transduction and the requirements for srfA induction in development of competence.

Authors:  J Hahn; D Dubnau
Journal:  J Bacteriol       Date:  1991-11       Impact factor: 3.490

4.  The Bacillus subtilis sin gene, a regulator of alternate developmental processes, codes for a DNA-binding protein.

Authors:  N K Gaur; J Oppenheim; I Smith
Journal:  J Bacteriol       Date:  1991-01       Impact factor: 3.490

5.  Characterization of the spo0A locus and its deduced product.

Authors:  F A Ferrari; K Trach; D LeCoq; J Spence; E Ferrari; J A Hoch
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

6.  Expression of competence genes in Bacillus subtilis.

Authors:  M Albano; J Hahn; D Dubnau
Journal:  J Bacteriol       Date:  1987-07       Impact factor: 3.490

7.  A small gene, designated comS, located within the coding region of the fourth amino acid-activation domain of srfA, is required for competence development in Bacillus subtilis.

Authors:  L W Hamoen; H Eshuis; J Jongbloed; G Venema; D van Sinderen
Journal:  Mol Microbiol       Date:  1995-01       Impact factor: 3.501

8.  Sequence and properties of mecA, a negative regulator of genetic competence in Bacillus subtilis.

Authors:  L Kong; K J Siranosian; A D Grossman; D Dubnau
Journal:  Mol Microbiol       Date:  1993-07       Impact factor: 3.501

9.  Regulation of competence-specific gene expression by Mec-mediated protein-protein interaction in Bacillus subtilis.

Authors:  L Kong; D Dubnau
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-21       Impact factor: 11.205

10.  Use of the Escherichia coli lac repressor and operator to control gene expression in Bacillus subtilis.

Authors:  D G Yansura; D J Henner
Journal:  Proc Natl Acad Sci U S A       Date:  1984-01       Impact factor: 11.205
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  34 in total

1.  Differential processing of propeptide inhibitors of Rap phosphatases in Bacillus subtilis.

Authors:  M Jiang; R Grau; M Perego
Journal:  J Bacteriol       Date:  2000-01       Impact factor: 3.490

2.  The pleiotropic response regulator DegU functions as a priming protein in competence development in Bacillus subtilis.

Authors:  L W Hamoen; A F Van Werkhoven; G Venema; D Dubnau
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-01       Impact factor: 11.205

3.  Control of a family of phosphatase regulatory genes (phr) by the alternate sigma factor sigma-H of Bacillus subtilis.

Authors:  R S McQuade; N Comella; A D Grossman
Journal:  J Bacteriol       Date:  2001-08       Impact factor: 3.490

4.  A MecA paralog, YpbH, binds ClpC, affecting both competence and sporulation.

Authors:  Marjan Persuh; Ines Mandic-Mulec; David Dubnau
Journal:  J Bacteriol       Date:  2002-04       Impact factor: 3.490

5.  Independent and interchangeable multimerization domains of the AbrB, Abh, and SpoVT global regulatory proteins.

Authors:  Fude Yao; Mark A Strauch
Journal:  J Bacteriol       Date:  2005-09       Impact factor: 3.490

6.  A macromolecular complex formed by a pilin-like protein in competent Bacillus subtilis.

Authors:  Inês Chen; Roberta Provvedi; David Dubnau
Journal:  J Biol Chem       Date:  2006-06-01       Impact factor: 5.157

7.  Antirepression as a second mechanism of transcriptional activation by a minor groove binding protein.

Authors:  Wiep Klaas Smits; Tran Thu Hoa; Leendert W Hamoen; Oscar P Kuipers; David Dubnau
Journal:  Mol Microbiol       Date:  2007-04       Impact factor: 3.501

8.  Transition state regulator AbrB inhibits transcription of Bacillus amyloliquefaciens FZB45 phytase through binding at two distinct sites located within the extended phyC promoter region.

Authors:  Oliwia Makarewicz; Svetlana Neubauer; Corinna Preusse; Rainer Borriss
Journal:  J Bacteriol       Date:  2008-08-01       Impact factor: 3.490

9.  Characterization of YvcJ, a conserved P-loop-containing protein, and its implication in competence in Bacillus subtilis.

Authors:  Jennifer Luciano; Elodie Foulquier; Jean-Raphael Fantino; Anne Galinier; Frédérique Pompeo
Journal:  J Bacteriol       Date:  2008-12-12       Impact factor: 3.490

10.  Effects of phosphorelay perturbations on architecture, sporulation, and spore resistance in biofilms of Bacillus subtilis.

Authors:  Jan-Willem Veening; Oscar P Kuipers; Stanley Brul; Klaas J Hellingwerf; Remco Kort
Journal:  J Bacteriol       Date:  2006-04       Impact factor: 3.490
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