Literature DB >> 11914365

A MecA paralog, YpbH, binds ClpC, affecting both competence and sporulation.

Marjan Persuh1, Ines Mandic-Mulec, David Dubnau.   

Abstract

ComK, the master regulator of competence, is degraded by the general stress-related protease ClpCP but must be targeted to this protease by binding to the adapter protein MecA. The genome of Bacillus subtilis contains a paralog of mecA, ypbH. We show in the present study that YpbH, like MecA, binds ClpC and that its elimination or overproduction affects competence and sporulation.

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Year:  2002        PMID： 11914365      PMCID： PMC134970          DOI： 10.1128/JB.184.8.2310-2313.2002

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  26 in total

1.  The N- and C-terminal domains of MecA recognize different partners in the competence molecular switch.

Authors:  M Persuh; K Turgay; I Mandic-Mulec; D Dubnau
Journal:  Mol Microbiol       Date:  1999-08       Impact factor: 3.501

2.  The pleiotropic response regulator DegU functions as a priming protein in competence development in Bacillus subtilis.

Authors:  L W Hamoen; A F Van Werkhoven; G Venema; D Dubnau
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-01       Impact factor: 11.205

3.  Rok (YkuW) regulates genetic competence in Bacillus subtilis by directly repressing comK.

Authors:  Tran Thu Hoa; Pablo Tortosa; Mark Albano; David Dubnau
Journal:  Mol Microbiol       Date:  2002-01       Impact factor: 3.501

4.  Suppression of early competence mutations in Bacillus subtilis by mec mutations.

Authors:  M Roggiani; J Hahn; D Dubnau
Journal:  J Bacteriol       Date:  1990-07       Impact factor: 3.490

5.  Growth medium-independent genetic competence mutants of Bacillus subtilis.

Authors:  D Dubnau; M Roggiani
Journal:  J Bacteriol       Date:  1990-07       Impact factor: 3.490

6.  Spo0A controls the sigma A-dependent activation of Bacillus subtilis sporulation-specific transcription unit spoIIE.

Authors:  K York; T J Kenney; S Satola; C P Moran; H Poth; P Youngman
Journal:  J Bacteriol       Date:  1992-04       Impact factor: 3.490

7.  Microarray analysis of the Bacillus subtilis K-state: genome-wide expression changes dependent on ComK.

Authors:  Randy M Berka; Jeanette Hahn; Mark Albano; Irena Draskovic; Marjan Persuh; Xianju Cui; Alan Sloma; William Widner; David Dubnau
Journal:  Mol Microbiol       Date:  2002-03       Impact factor: 3.501

8.  Expression of competence genes in Bacillus subtilis.

Authors:  M Albano; J Hahn; D Dubnau
Journal:  J Bacteriol       Date:  1987-07       Impact factor: 3.490

9.  Sequence and properties of mecA, a negative regulator of genetic competence in Bacillus subtilis.

Authors:  L Kong; K J Siranosian; A D Grossman; D Dubnau
Journal:  Mol Microbiol       Date:  1993-07       Impact factor: 3.501

10.  Biochemical and genetic characterization of a competence pheromone from B. subtilis.

Authors:  R Magnuson; J Solomon; A D Grossman
Journal:  Cell       Date:  1994-04-22       Impact factor: 41.582
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  22 in total

1.  MecA, an adaptor protein necessary for ClpC chaperone activity.

Authors:  Tilman Schlothauer; Axel Mogk; David A Dougan; Bernd Bukau; Kürşad Turgay
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-21       Impact factor: 11.205

2.  Adaptor protein MecA is a negative regulator of the expression of late competence genes in Streptococcus thermophilus.

Authors:  Céline Boutry; Astrid Wahl; Brigitte Delplace; André Clippe; Laetitia Fontaine; Pascal Hols
Journal:  J Bacteriol       Date:  2012-01-27       Impact factor: 3.490

3.  Adaptor protein controlled oligomerization activates the AAA+ protein ClpC.

Authors:  Janine Kirstein; Tilman Schlothauer; David A Dougan; Hauke Lilie; Gilbert Tischendorf; Axel Mogk; Bernd Bukau; Kürşad Turgay
Journal:  EMBO J       Date:  2006-03-09       Impact factor: 11.598

4.  Degradation of SsrA-tagged proteins in streptococci.

Authors:  Liang Tao; Indranil Biswas
Journal:  Microbiology       Date:  2015-02-02       Impact factor: 2.777

Review 5.  Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases.

Authors:  Janine Kirstein; Noël Molière; David A Dougan; Kürşad Turgay
Journal:  Nat Rev Microbiol       Date:  2009-08       Impact factor: 60.633

6.  Molecular determinants of MecA as a degradation tag for the ClpCP protease.

Authors:  Ziqing Mei; Feng Wang; Yutao Qi; Zhiyuan Zhou; Qi Hu; Han Li; Jiawei Wu; Yigong Shi
Journal:  J Biol Chem       Date:  2009-09-18       Impact factor: 5.157

7.  Degradation of phycobilisomes in Synechocystis sp. PCC6803: evidence for essential formation of an NblA1/NblA2 heterodimer and its codegradation by A Clp protease complex.

Authors:  Antje Baier; Wiebke Winkler; Thomas Korte; Wolfgang Lockau; Anne Karradt
Journal:  J Biol Chem       Date:  2014-03-07       Impact factor: 5.157

8.  Geobacillus thermodenitrificans YjbH recognizes the C-terminal end of Bacillus subtilis Spx to accelerate Spx proteolysis by ClpXP.

Authors:  Chio Mui Chan; Saurabh Garg; Ann A Lin; Peter Zuber
Journal:  Microbiology       Date:  2012-02-16       Impact factor: 2.777

9.  The YjbH protein of Bacillus subtilis enhances ClpXP-catalyzed proteolysis of Spx.

Authors:  Saurabh K Garg; Sushma Kommineni; Luke Henslee; Ying Zhang; Peter Zuber
Journal:  J Bacteriol       Date:  2008-12-12       Impact factor: 3.490

Review 10.  Roles of adaptor proteins in regulation of bacterial proteolysis.

Authors:  Aurelia Battesti; Susan Gottesman
Journal:  Curr Opin Microbiol       Date:  2013-01-31       Impact factor: 7.934
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