OBJECTIVE: To reproduce findings from previous reports that non-inherited maternal HLA class II antigens might contribute to rheumatoid arthritis (RA) susceptibility in the offspring. METHODS: Families were recruited from the Arthritis and Rheumatism Council's National Repository of RA families and HLA-DRB1 alleles were examined in these individuals and their first degree relatives using DNA typing methods. RESULTS: There was no evidence of an increase in either non-inherited maternal HLA-DR4 or the HLA-DRB1 shared epitope as a whole compared with the frequency expected using the non-inherited paternal antigens as controls. CONCLUSIONS: The numbers of probands who were shared epitope negative were small, but we are unable to confirm in these families the findings that non-inherited maternal HLA contributes an additional susceptibility factor to rheumatoid arthritis.
OBJECTIVE: To reproduce findings from previous reports that non-inherited maternal HLA class II antigens might contribute to rheumatoid arthritis (RA) susceptibility in the offspring. METHODS: Families were recruited from the Arthritis and Rheumatism Council's National Repository of RA families and HLA-DRB1 alleles were examined in these individuals and their first degree relatives using DNA typing methods. RESULTS: There was no evidence of an increase in either non-inherited maternal HLA-DR4 or the HLA-DRB1 shared epitope as a whole compared with the frequency expected using the non-inherited paternal antigens as controls. CONCLUSIONS: The numbers of probands who were shared epitope negative were small, but we are unable to confirm in these families the findings that non-inherited maternal HLA contributes an additional susceptibility factor to rheumatoid arthritis.
Authors: F C Arnett; S M Edworthy; D A Bloch; D J McShane; J F Fries; N S Cooper; L A Healey; S R Kaplan; M H Liang; H S Luthra Journal: Arthritis Rheum Date: 1988-03
Authors: Anouk L Feitsma; Jane Worthington; Annette H M van der Helm-van Mil; Darren Plant; Wendy Thomson; Jennie Ursum; Dirkjan van Schaardenburg; Irene E van der Horst-Bruinsma; Jon J van Rood; Tom W J Huizinga; René E M Toes; René R P de Vries Journal: Proc Natl Acad Sci U S A Date: 2007-12-06 Impact factor: 11.205
Authors: I E van der Horst-Bruinsma; J M Hazes; G M Schreuder; T R Radstake; P Barrera; L B van de Putte; D Mustamu; D van Schaardenburg; F C Breedveld; R R de Vries Journal: Ann Rheum Dis Date: 1998-11 Impact factor: 19.103
Authors: Hsin-Ju Hsieh; Christina G S Palmer; Sinead Harney; Hsiu-Wen Chen; Lara Bauman; Matthew A Brown; Janet S Sinsheimer Journal: BMC Proc Date: 2007-12-18