Literature DB >> 1280845

Population genetics of rheumatoid arthritis.

W Ollier1, W Thomson.   

Abstract

A major component of genetic susceptibility to rheumatoid arthritis (RA) appears to be explained by inheritance of HLA-DRB1 alleles, which have a conserved sequence of amino acids in the third hyper-variable region of the molecule. This "shared epitope" is found on various DR4, DR1, and DR6 variants, as well as on DR10. The evidence for this "shared epitope" in RA is examined at the population level, including how it fits in with the available epidemiologic data and RA disease severity.

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Year:  1992        PMID： 1280845

Source DB:  PubMed          Journal:  Rheum Dis Clin North Am        ISSN： 0889-857X            Impact factor:   2.670


  32 in total

1.  Clinical and immunogenetic characteristics of European multicase rheumatoid arthritis families.

Authors:  A Balsa; P Barrera; R Westhovens; H Alves; K Maenaut; D Pascual-Salcedo; F Cornélis; T Bardin; L Riente; T R Radstake; G de Almeida; V Lepage; C Stravopoulos; M Spaepen; A Lopes-Vaz; D Charron; M Martinez; J F Prudhomme; P Migliorini; P Fritz
Journal:  Ann Rheum Dis       Date:  2001-06       Impact factor: 19.103

2.  HLA-DR-DQ haplotypes and genotypes in Finnish patients with rheumatoid arthritis.

Authors:  S Laivoranta-Nyman; T Möttönen; R Hermann; J Tuokko; R Luukkainen; M Hakala; P Hannonen; M Korpela; U Yli-Kerttula; A Toivanen; J Ilonen
Journal:  Ann Rheum Dis       Date:  2004-11       Impact factor: 19.103

3.  The shared epitope is a marker of severity associated with selection for, but not with response to, infliximab in a large rheumatoid arthritis population.

Authors:  H Marotte; B Pallot-Prades; L Grange; J Tebib; P Gaudin; C Alexandre; J L Blond; M A Cazalis; B Mougin; P Miossec
Journal:  Ann Rheum Dis       Date:  2005-08-11       Impact factor: 19.103

Review 4.  Molecular mechanisms involved in the association of HLA-DR4 and rheumatoid arthritis.

Authors:  I Auger; E Toussirot; J Roudier
Journal:  Immunol Res       Date:  1997-02       Impact factor: 2.829

Review 5.  Should patients with recent onset rheumatoid arthritis be offered genetic screening?

Authors:  D P Symmons; W E Ollier; P Brennan; A J Silman
Journal:  Ann Rheum Dis       Date:  1996-07       Impact factor: 19.103

6.  HLA sharing and history of miscarriage among women with rheumatoid arthritis.

Authors:  P Brennan
Journal:  Am J Hum Genet       Date:  1997-03       Impact factor: 11.025

Review 7.  Genetic influences on rheumatoid arthritis in African Americans.

Authors:  Laura B Hughes; Larry W Moreland; S Louis Bridges
Journal:  Immunol Res       Date:  2002       Impact factor: 2.829

8.  Contribution of HLA-DRB1*04 alleles and anti-cyclic citrullinated antibodies to development of resistance to disease-modifying antirheumatic drugs in early rheumatoid arthritis.

Authors:  Shunsuke Mori; Jun Hirose; Kensuke Yonemura
Journal:  Clin Rheumatol       Date:  2010-04-11       Impact factor: 2.980

9.  Severe disease in patients with rheumatoid arthritis carrying a mutation in the Mediterranean fever gene.

Authors:  E Rabinovich; A Livneh; P Langevitz; N Brezniak; E Shinar; M Pras; Y Shinar
Journal:  Ann Rheum Dis       Date:  2005-07       Impact factor: 19.103

Review 10.  Advances in the treatment of cervical rheumatoid: Less surgery and less morbidity.

Authors:  Grant W Mallory; Sasha R Halasz; Michelle J Clarke
Journal:  World J Orthop       Date:  2014-07-18
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