Literature DB >> 7761436

Isolation and characterization of a MAGE gene family in the Xp21.3 region.

F Muscatelli1, A P Walker, E De Plaen, A N Stafford, A P Monaco.   

Abstract

A human gene with strong homology to the MAGE gene family located in Xq27-qter has been isolated by using exon-trapping of cosmids in the Xp21.3 region. We have mapped and sequenced cDNA and genomic clones corresponding to this gene, MAGE-Xp, and shown that the last exon contains the open reading frame and is present in a minimum of five copies in a 30-kb interval. MAGE-Xp is expressed only in testis and, unlike the Xq27-qter MAGE genes, it is not expressed in any of 12 different tumor tissues tested. However, the gene and predicted protein structure are conserved, suggesting a similar function. MAGE-Xp is located in the 160-kb critical interval defined for the locus involved in sex determination within Xp21 and is 50 kb distal to the DAX-1 gene, which is responsible for X-chromosome-linked adrenal hypoplasia congenita.

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Year:  1995        PMID： 7761436      PMCID： PMC41832          DOI： 10.1073/pnas.92.11.4987

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

1.  Basic local alignment search tool.

Authors:  S F Altschul; W Gish; W Miller; E W Myers; D J Lipman
Journal:  J Mol Biol       Date:  1990-10-05       Impact factor: 5.469

2.  Yeast artificial chromosome libraries containing large inserts from mouse and human DNA.

Authors:  Z Larin; A P Monaco; H Lehrach
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

3.  Hydrophobic cluster analysis: an efficient new way to compare and analyse amino acid sequences.

Authors:  C Gaboriaud; V Bissery; T Benchetrit; J P Mornon
Journal:  FEBS Lett       Date:  1987-11-16       Impact factor: 4.124

4.  A novel brain-specific mRNA encoding nuclear protein (necdin) expressed in neurally differentiated embryonal carcinoma cells.

Authors:  K Maruyama; M Usami; T Aizawa; K Yoshikawa
Journal:  Biochem Biophys Res Commun       Date:  1991-07-15       Impact factor: 3.575

5.  A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma.

Authors:  P van der Bruggen; C Traversari; P Chomez; C Lurquin; E De Plaen; B Van den Eynde; A Knuth; T Boon
Journal:  Science       Date:  1991-12-13       Impact factor: 47.728

6.  Expression of necdin, an embryonal carcinoma-derived nuclear protein, in developing mouse brain.

Authors:  T Aizawa; K Maruyama; H Kondo; K Yoshikawa
Journal:  Brain Res Dev Brain Res       Date:  1992-08-21

7.  Exon amplification: a strategy to isolate mammalian genes based on RNA splicing.

Authors:  A J Buckler; D D Chang; S L Graw; J D Brook; D A Haber; P A Sharp; D E Housman
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-01       Impact factor: 11.205

8.  A nonapeptide encoded by human gene MAGE-1 is recognized on HLA-A1 by cytolytic T lymphocytes directed against tumor antigen MZ2-E.

Authors:  C Traversari; P van der Bruggen; I F Luescher; C Lurquin; P Chomez; A Van Pel; E De Plaen; A Amar-Costesec; T Boon
Journal:  J Exp Med       Date:  1992-11-01       Impact factor: 14.307

9.  An unusual member of the nuclear hormone receptor superfamily responsible for X-linked adrenal hypoplasia congenita.

Authors:  E Zanaria; F Muscatelli; B Bardoni; T M Strom; S Guioli; W Guo; E Lalli; C Moser; A P Walker; E R McCabe
Journal:  Nature       Date:  1994-12-15       Impact factor: 49.962

10.  Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism.

Authors:  F Muscatelli; T M Strom; A P Walker; E Zanaria; D Récan; A Meindl; B Bardoni; S Guioli; G Zehetner; W Rabl
Journal:  Nature       Date:  1994-12-15       Impact factor: 49.962
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  23 in total

1.  The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation.

Authors:  C De Smet; O De Backer; I Faraoni; C Lurquin; F Brasseur; T Boon
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-09       Impact factor: 11.205

Review 2.  Cytolytic T lymphocyte responses of cancer patients to tumor-associated antigens.

Authors:  P Romero
Journal:  Springer Semin Immunopathol       Date:  1996

Review 3.  Tumour antigens recognized by T lymphocytes: at the core of cancer immunotherapy.

Authors:  Pierre G Coulie; Benoît J Van den Eynde; Pierre van der Bruggen; Thierry Boon
Journal:  Nat Rev Cancer       Date:  2014-02       Impact factor: 60.716

4.  Induction of antigen-specific tumor immunity by genetic and cellular vaccines against MAGE: enhanced tumor protection by coexpression of granulocyte-macrophage colony-stimulating factor and B7-1.

Authors:  H Büeler; R C Mulligan
Journal:  Mol Med       Date:  1996-09       Impact factor: 6.354

5.  The SMAGE gene family is expressed in post-meiotic spermatids during mouse germ cell differentiation.

Authors:  P Chomez; R Williams; O De Backer; T Boon; B Vennström
Journal:  Immunogenetics       Date:  1996       Impact factor: 2.846

6.  PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus.

Authors:  U Brinkmann; G Vasmatzis; B Lee; N Yerushalmi; M Essand; I Pastan
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205

7.  MAGE-A1 interacts with adaptor SKIP and the deacetylase HDAC1 to repress transcription.

Authors:  Sandra Laduron; Rachel Deplus; Sifang Zhou; Olga Kholmanskikh; Danièle Godelaine; Charles De Smet; S Diane Hayward; François Fuks; Thierry Boon; Etienne De Plaen
Journal:  Nucleic Acids Res       Date:  2004-08-17       Impact factor: 16.971

Review 8.  Somatic gene copy number alterations in colorectal cancer: new quest for cancer drivers and biomarkers.

Authors:  H Wang; L Liang; J-Y Fang; J Xu
Journal:  Oncogene       Date:  2015-08-10       Impact factor: 9.867

9.  The significance of MAGED4 expression in non-small cell lung cancer as analyzed by real-time fluorescence quantitative PCR.

Authors:  Qin-Yun Ma; Lie-Wen Pang; Zhi-Ming Chen; Yong-Jun Zhu; Gang Chen; Ji Chen
Journal:  Oncol Lett       Date:  2012-07-04       Impact factor: 2.967

10.  Evaluation of MAGE-1 and MAGE-3 as tumour-specific markers to detect blood dissemination of hepatocellular carcinoma cells.

Authors:  D-C Mou; S-L Cai; J-R Peng; Y Wang; H-S Chen; X-W Pang; X-S Leng; W-F Chen
Journal:  Br J Cancer       Date:  2002-01-07       Impact factor: 7.640
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