Literature DB >> 26257062

Somatic gene copy number alterations in colorectal cancer: new quest for cancer drivers and biomarkers.

H Wang1, L Liang1, J-Y Fang1, J Xu1.   

Abstract

Colorectal cancer (CRC) results from the accumulation of genetic alterations, and somatic copy number alterations (CNAs) are crucial for the development of CRC. Genome-wide survey of CNAs provides opportunities for identifying cancer driver genes in an unbiased manner. The detection of aberrant CNAs may provide novel markers for the early diagnosis and personalized treatment of CRC. A major challenge in array-based profiling of CNAs is to distinguish the alterations that play causative roles from the random alterations that accumulate during colorectal carcinogenesis. In this view, we systematically discuss the frequent CNAs in CRC, focusing on functional genes that have potential diagnostic, prognostic and therapeutic significance.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 26257062     DOI： 10.1038/onc.2015.304

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  154 in total

Review 1.  Apoptosis induction by Bcl-2 proteins independent of the BH3 domain.

Authors:  Amir M Hossini; Jürgen Eberle
Journal:  Biochem Pharmacol       Date:  2008-08-22       Impact factor: 5.858

2.  A lung cancer gene GPC5 could also be crucial in breast cancer.

Authors:  Changwen Zhang; Shuping Zhang; Daoqiang Zhang; Zhihong Zhang; Yong Xu; Sijin Liu
Journal:  Mol Genet Metab       Date:  2011-02-12       Impact factor: 4.797

3.  Deleted in Colorectal Cancer (DCC) encodes a netrin receptor.

Authors:  K Keino-Masu; M Masu; L Hinck; E D Leonardo; S S Chan; J G Culotti; M Tessier-Lavigne
Journal:  Cell       Date:  1996-10-18       Impact factor: 41.582

4.  DEOD: uncovering dominant effects of cancer-driver genes based on a partial covariance selection method.

Authors:  Bayarbaatar Amgalan; Hyunju Lee
Journal:  Bioinformatics       Date:  2015-03-26       Impact factor: 6.937

5.  Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer.

Authors:  Lenora W M Loo; Maarit Tiirikainen; Iona Cheng; Annette Lum-Jones; Ann Seifried; James M Church; Robert Gryfe; Daniel J Weisenberger; Noralane M Lindor; Steven Gallinger; Robert W Haile; David J Duggan; Stephen N Thibodeau; Graham Casey; Loïc Le Marchand
Journal:  Genes Chromosomes Cancer       Date:  2013-01-23       Impact factor: 5.006

6.  K-RAS point mutation, and amplification of C-MYC and C-ERBB2 in colon adenocarcinoma.

Authors:  Wiesław Kruszewski; Renata Kowara; Robert Rzepko; Cezary Warezak; Jacek Zieliński; Grzegorz Gryglewski; Andrzej Kopacz; Tomasz Jastrzebski; Tadeusz Pawełczyk
Journal:  Folia Histochem Cytobiol       Date:  2004       Impact factor: 1.698

7.  Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers.

Authors:  C L Wu; S D Kirley; H Xiao; Y Chuang; D C Chung; L R Zukerberg
Journal:  Cancer Res       Date:  2001-10-01       Impact factor: 12.701

Review 8.  Multiple pathways regulated by the tumor suppressor PP2A in transformation.

Authors:  Jukka Westermarck; William C Hahn
Journal:  Trends Mol Med       Date:  2008-03-10       Impact factor: 11.951

9.  Gender-associated genomic differences in colorectal cancer: clinical insight from feminization of male cancer cells.

Authors:  Rola H Ali; Makia J Marafie; Milad S Bitar; Fahad Al-Dousari; Samar Ismael; Hussain Bin Haider; Waleed Al-Ali; Sindhu P Jacob; Fahd Al-Mulla
Journal:  Int J Mol Sci       Date:  2014-09-29       Impact factor: 5.923

10.  The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer.

Authors:  Wei-Cheng Liang; Wei-Ming Fu; Cheuk-Wa Wong; Yan Wang; Wei-Mao Wang; Guo-Xin Hu; Li Zhang; Li-Jia Xiao; David Chi-Cheong Wan; Jin-Fang Zhang; Mary Miu-Yee Waye
Journal:  Oncotarget       Date:  2015-09-08
View more
  47 in total

1.  Insights into Impact of DNA Copy Number Alteration and Methylation on the Proteogenomic Landscape of Human Ovarian Cancer via a Multi-omics Integrative Analysis.

Authors:  Xiaoyu Song; Jiayi Ji; Kevin J Gleason; Fan Yang; John A Martignetti; Lin S Chen; Pei Wang
Journal:  Mol Cell Proteomics       Date:  2019-06-21       Impact factor: 5.911

2.  Personalised mapping of tumour development in synchronous colorectal cancer patients.

Authors:  Valentina Thomas; Maura B Cotter; Miriam Tosetto; Yi Ling Khaw; Robert Geraghty; Desmond C Winter; Elizabeth J Ryan; Kieran Sheahan; Simon J Furney
Journal:  NPJ Genom Med       Date:  2020-07-03       Impact factor: 8.617

3.  Copy number variation of ubiquitin- specific proteases genes in blood leukocytes and colorectal cancer.

Authors:  Tian Tian; Haoran Bi; Yupeng Liu; Guangxiao Li; Yiwei Zhang; Liming Cao; Fulan Hu; Yashuang Zhao; Huiping Yuan
Journal:  Cancer Biol Ther       Date:  2020-05-04       Impact factor: 4.742

4.  Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.

Authors:  Brenton R Paolella; William J Gibson; Laura M Urbanski; John A Alberta; Travis I Zack; Pratiti Bandopadhayay; Caitlin A Nichols; Pankaj K Agarwalla; Meredith S Brown; Rebecca Lamothe; Yong Yu; Peter S Choi; Esther A Obeng; Dirk Heckl; Guo Wei; Belinda Wang; Aviad Tsherniak; Francisca Vazquez; Barbara A Weir; David E Root; Glenn S Cowley; Sara J Buhrlage; Charles D Stiles; Benjamin L Ebert; William C Hahn; Robin Reed; Rameen Beroukhim
Journal:  Elife       Date:  2017-02-08       Impact factor: 8.140

5.  KRAS Gene Copy Number as a Negative Predictive Biomarker for the Treatment of Metastatic Rectal Cancer With Cetuximab: A Case Report.

Authors:  Qunli Xiong; Zhu Zeng; Yang Yang; Ya Wang; Yongfeng Xu; Ying Zhou; Jinlu Liu; Zhiwei Zhang; Meng Qiu; Qing Zhu
Journal:  Front Oncol       Date:  2022-05-26       Impact factor: 5.738

6.  Taxane-mediated radiosensitization derives from chromosomal missegregation on tripolar mitotic spindles orchestrated by AURKA and TPX2.

Authors:  M Orth; K Unger; U Schoetz; C Belka; K Lauber
Journal:  Oncogene       Date:  2017-09-04       Impact factor: 9.867

7.  Comparison of EpCAMhighCD44+ cancer stem cells with EpCAMhighCD44- tumor cells in colon cancer by single-cell sequencing.

Authors:  Mingshan Liu; Jiabo Di; Yang Liu; Zhe Su; Beihai Jiang; Zaozao Wang; Xiangqian Su
Journal:  Cancer Biol Ther       Date:  2018-04-12       Impact factor: 4.742

8.  Significant association and synergistic adverse prognostic effect of podocalyxin-like protein and epidermal growth factor receptor expression in colorectal cancer.

Authors:  Anna H Larsson; Sophie Lehn; Sakarias Wangefjord; Emelie Karnevi; Eugenia Kuteeva; Magnus Sundström; Björn Nodin; Mathias Uhlén; Jakob Eberhard; Helgi Birgisson; Karin Jirström
Journal:  J Transl Med       Date:  2016-05-10       Impact factor: 5.531

9.  Mutational Analysis Identifies Therapeutic Biomarkers in Inflammatory Bowel Disease-Associated Colorectal Cancers.

Authors:  Shahida Din; Kim Wong; Mike F Mueller; Anca Oniscu; James Hewinson; Catherine J Black; Martin L Miller; Alejandro Jiménez-Sánchez; Roy Rabbie; Mamunar Rashid; Jack Satsangi; David J Adams; Mark J Arends
Journal:  Clin Cancer Res       Date:  2018-06-27       Impact factor: 12.531

10.  Gain-of-function miRNA signature by mutant p53 associates with poor cancer outcome.

Authors:  Yao Zhang; Ye Hu; Jing-Yuan Fang; Jie Xu
Journal:  Oncotarget       Date:  2016-03-08
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.