Literature DB >> 7761428

Accumulation of plasma cells in atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits.

Y Sohma1, H Sasano, R Shiga, S Saeki, T Suzuki, H Nagura, M Nose, T Yamamoto.   

Abstract

By screening a cDNA library constructed from aortic total RNA derived from Watanabe heritable hyperlipidemic (WHHL) rabbits by differential hybridization, we have obtained a cDNA encoding the kappa light chain of immunoglobulin. Northern blot analysis of total RNA prepared from aortas of WHHL and normal rabbits of various ages revealed that this light-chain mRNA accumulates gradually with age in aortas in WHHL rabbits. Northern blotting and in situ hybridization with an antisense oligonucleotide specific to rabbit immunoglobulin gamma heavy-chain mRNA also detected accumulation of this heavy-chain mRNA in advanced lesions of WHHL rabbit aortas. Moreover, immunohistochemical and electron microscopic analyses demonstrated the presence of plasma cells in the atherosclerotic lesions.

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Year:  1995        PMID： 7761428      PMCID： PMC41822          DOI： 10.1073/pnas.92.11.4937

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

1.  A simple and very efficient method for generating cDNA libraries.

Authors:  U Gubler; B J Hoffman
Journal:  Gene       Date:  1983-11       Impact factor: 3.688

2.  cDNA clone encoding a complete rabbit immunoglobulin kappa light chain of b4 allotype.

Authors:  K L Dreher; L Emorine; T J Kindt; E E Max
Journal:  Proc Natl Acad Sci U S A       Date:  1983-07       Impact factor: 11.205

3.  A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

Authors:  A P Feinberg; B Vogelstein
Journal:  Anal Biochem       Date:  1983-07-01       Impact factor: 3.365

4.  Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit.

Authors:  T Yamamoto; R W Bishop; M S Brown; J L Goldstein; D W Russell
Journal:  Science       Date:  1986-06-06       Impact factor: 47.728

5.  Kinetic defects in the processing of the low density lipoprotein receptor in fibroblasts from WHHL rabbits and a family with familial hypercholesterolemia.

Authors:  W J Schneider; M S Brown; J L Goldstein
Journal:  Mol Biol Med       Date:  1983-10

6.  Cellular pathology of progressive atherosclerosis in the WHHL rabbit. An animal model of familial hypercholesterolemia.

Authors:  L M Buja; T Kita; J L Goldstein; Y Watanabe; M S Brown
Journal:  Arteriosclerosis       Date:  1983 Jan-Feb

7.  Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL-rabbit).

Authors:  Y Watanabe
Journal:  Atherosclerosis       Date:  1980-06       Impact factor: 5.162

8.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

9.  Expression of mRNA for matrix gamma-carboxyglutamic acid protein during progression of atherosclerosis in aortae of Watanabe heritable hyperlipidemic rabbits.

Authors:  Y Sohma; T Suzuki; H Sasano; H Nagura; M Nose; T Yamamoto
Journal:  J Biochem       Date:  1994-10       Impact factor: 3.387

10.  Deficiency of low density lipoprotein receptors in liver and adrenal gland of the WHHL rabbit, an animal model of familial hypercholesterolemia.

Authors:  T Kita; M S Brown; Y Watanabe; J L Goldstein
Journal:  Proc Natl Acad Sci U S A       Date:  1981-04       Impact factor: 11.205
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  5 in total

1.  Expression of low-density lipoprotein receptors in peripheral blood and tonsil B lymphocytes.

Authors:  J B De Sanctis; I Blanca; H Rivera; N E Bianco
Journal:  Clin Exp Immunol       Date:  1998-08       Impact factor: 4.330

2.  Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response.

Authors:  Emilie K Grasset; Amanda Duhlin; Hanna E Agardh; Olga Ovchinnikova; Thomas Hägglöf; Mattias N Forsell; Gabrielle Paulsson-Berne; Göran K Hansson; Daniel F J Ketelhuth; Mikael C I Karlsson
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-06       Impact factor: 11.205

3.  Reactivity of peripheral blood lymphocytes to oxidized low-density lipoprotein: a novel system to estimate atherosclerosis employing the Cellscan.

Authors:  N Zurgil; Y Levy; M Deutsch; B Gilburd; J George; D Harats; M Kaufman; Y Shoenfeld
Journal:  Clin Cardiol       Date:  1999-08       Impact factor: 2.882

4.  Screening of a HUAEC cDNA library identifies actin as a candidate autoantigen associated with carotid atherosclerosis.

Authors:  P Margutti; F Delunardo; M Sorice; G Valesini; C Alessandri; R Capoano; E Profumo; A Siracusano; B Salvati; R Riganò; E Ortona
Journal:  Clin Exp Immunol       Date:  2004-07       Impact factor: 4.330

Review 5.  Vaccination and atherosclerosis.

Authors:  Xinghua Zhou; Göran K Hansson
Journal:  Curr Atheroscler Rep       Date:  2004-03       Impact factor: 5.113
  5 in total

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