Literature DB >> 7406953

Serial inbreeding of rabbits with hereditary hyperlipidemia (WHHL-rabbit).

Y Watanabe.   

Abstract

The WHHL-rabbit (Watanabe-heritable hyperlipidemic rabbit) is a strain of rabbit with a consistently inherited hyperlipidemic trait produced by inbreeding from a mutant discovered in 1973. (1) The alleles for this trait have been inherited unfailingly to yield a total of 154 WHHL-rabbits to date. (2) These rabbits showed abnormally increased serum levels of cholesterol (S-Ch) and triglyceride (S-TG) at various ages, increased approximately 8- to 14-fold in comparison with control levels in normal Japanese white rabbits. The serum lipoproteins displayed an electrophoretic pattern characterized by a broad beta-lipoprotein band a markedly diminished alpha-lipoprotein band. (3) Necropsy examination performed on 75 WHHL-rabbits showed spontaneous development of aortic atherosclerosis in all cases over 5 months of age (63/63) and xanthoma of digital joints in 60% of cases from the ages of about 16 months.

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Year:  1980        PMID： 7406953     DOI： 10.1016/0021-9150(80)90234-8

Source DB:  PubMed          Journal:  Atherosclerosis        ISSN： 0021-9150            Impact factor:   5.162


  81 in total

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5.  Studies on fine structure and location of lipids in quick-freeze replicas of atherosclerotic aorta of WHHL rabbits.

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6.  A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes.

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7.  Delayed clearance of very low density and intermediate density lipoproteins with enhanced conversion to low density lipoprotein in WHHL rabbits.

Authors:  T Kita; M S Brown; D W Bilheimer; J L Goldstein
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8.  Unexpected inhibition of cholesterol 7 alpha-hydroxylase by cholesterol in New Zealand white and Watanabe heritable hyperlipidemic rabbits.

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9.  The relative atherogenicity of VLDL and LDL is dependent on the topographic site.

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10.  Probucol inhibits not only the progression of atherosclerotic disease, but causes a different composition of atherosclerotic lesions in WHHL-rabbits.

Authors:  J H Braesen; U Beisiegel; A Niendorf
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