| Literature DB >> 7723548 |
E A Sullivan1, B N Kreiswirth, L Palumbo, V Kapur, J M Musser, A Ebrahimzadeh, T R Frieden.
Abstract
22 patients infected with fluoroquinolone-resistant Mycobacterium tuberculosis in New York City were identified between January, 1991, and November, 1993. In 16 patients resistance arose as a result of inadequate or inappropriate treatment. 6 patients had primary infection with fluoroquinolone-resistant organisms; 5 acquired the organisms nosocomially. Seven distinct patterns of restriction-fragment length polymorphism were identified in isolates from 21 patients. Fluoroquinolones should be restricted to patients with multidrug-resistant disease or intolerance to other antituberculosis drugs. All patients with multidrug-resistant tuberculosis should be on directly observed therapy.Entities:
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Year: 1995 PMID： 7723548 DOI： 10.1016/s0140-6736(95)90980-x
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321