Literature DB >> 7702657

Human and E.coli excinucleases are affected differently by the sequence context of acetylaminofluorene-guanine adduct.

D Mu1, E Bertrand-Burggraf, J C Huang, R P Fuchs, A Sancar, B P Fuchs.   

Abstract

Synthetic DNA substrates containing an acetylaminofluorene (AAF) adduct at each of the three guanine in the G1G2CG3CC sequence were constructed and tested as substrates for reconstituted E.coli (A)BC excinuclease and human excinuclease in HeLa cell-free extract (CFE). The (A)BC excinulcease repaired the three substrates with relative efficiencies of G1:G2:G3 of 100:18:66 in agreement with an earlier report [Seeberg, E., and Fuchs, R.P.P. (1990) Proc. Natl Acad. Sci. USA 87, 191-194]. The same lesions were repaired by the human excinuclease with the strikingly different efficiencies of G1:G2:G3 as 38:100:68. These results reveal that the human excinuclease is affected by the sequence context of the lesion in a different manner than its prokaryotic counterpart.

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Year:  1994        PMID： 7702657      PMCID： PMC523749          DOI： 10.1093/nar/22.23.4869

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  13 in total

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Authors:  B K Jones; A T Yeung
Journal:  J Biol Chem       Date:  1990-02-25       Impact factor: 5.157

2.  Endonuclease VII of phage T4 nicks N-2-acetylaminofluorene-induced DNA structures in vitro.

Authors:  E Bertrand-Burggraf; B Kemper; R P Fuchs
Journal:  Mutat Res       Date:  1994-05       Impact factor: 2.433

3.  Effect of sequence, adduct type, and opposing lesions on the binding and repair of ultraviolet photodamage by DNA photolyase and (A)BC excinuclease.

Authors:  D L Svoboda; C A Smith; J S Taylor; A Sancar
Journal:  J Biol Chem       Date:  1993-05-15       Impact factor: 5.157

4.  DNA binding spectrum of the carcinogen N-acetoxy-N-2-acetylaminofluorene significantly differs from the mutation spectrum.

Authors:  R P Fuchs
Journal:  J Mol Biol       Date:  1984-07-25       Impact factor: 5.469

5.  DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract.

Authors:  J L Manley; A Fire; A Cano; P A Sharp; M L Gefter
Journal:  Proc Natl Acad Sci U S A       Date:  1980-07       Impact factor: 11.205

6.  Acetylaminofluorene bound to different guanines of the sequence -GGCGCC- is excised with different efficiencies by the UvrABC excision nuclease in a pattern not correlated to the potency of mutation induction.

Authors:  E Seeberg; R P Fuchs
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

7.  Construction of plasmids containing a unique acetylaminofluorene adduct located within a mutation hot spot. A new probe for frameshift mutagenesis.

Authors:  P Koehl; D Burnouf; R P Fuchs
Journal:  J Mol Biol       Date:  1989-05-20       Impact factor: 5.469

8.  Mutagenic replication in human cell extracts of DNA containing site-specific N-2-acetylaminofluorene adducts.

Authors:  D C Thomas; X Veaute; T A Kunkel; R P Fuchs
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-02       Impact factor: 11.205

9.  Sequence effect on incision by (A)BC excinuclease of 4NQO adducts and UV photoproducts.

Authors:  D C Thomas; I Husain; S G Chaney; G B Panigrahi; I G Walker
Journal:  Nucleic Acids Res       Date:  1991-01-25       Impact factor: 16.971

10.  Human nucleotide excision nuclease removes thymine dimers from DNA by incising the 22nd phosphodiester bond 5' and the 6th phosphodiester bond 3' to the photodimer.

Authors:  J C Huang; D L Svoboda; J T Reardon; A Sancar
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-15       Impact factor: 11.205
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  18 in total

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2.  Single-stranded DNA Binding by the Helix-Hairpin-Helix Domain of XPF Protein Contributes to the Substrate Specificity of the ERCC1-XPF Protein Complex.

Authors:  Devashish Das; Maryam Faridounnia; Lidija Kovacic; Robert Kaptein; Rolf Boelens; Gert E Folkers
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3.  Probing for DNA damage with β-hairpins: similarities in incision efficiencies of bulky DNA adducts by prokaryotic and human nucleotide excision repair systems in vitro.

Authors:  Yang Liu; Dara Reeves; Konstantin Kropachev; Yuqin Cai; Shuang Ding; Marina Kolbanovskiy; Alexander Kolbanovskiy; Judith L Bolton; Suse Broyde; Bennett Van Houten; Nicholas E Geacintov
Journal:  DNA Repair (Amst)       Date:  2011-07-08

4.  Nucleotide excision repair efficiencies of bulky carcinogen-DNA adducts are governed by a balance between stabilizing and destabilizing interactions.

Authors:  Yuqin Cai; Nicholas E Geacintov; Suse Broyde
Journal:  Biochemistry       Date:  2012-02-09       Impact factor: 3.162

5.  An Integrated Approach for Analysis of the DNA Damage Response in Mammalian Cells: NUCLEOTIDE EXCISION REPAIR, DNA DAMAGE CHECKPOINT, AND APOPTOSIS.

Authors:  Jun-Hyuk Choi; So-Young Kim; Sook-Kyung Kim; Michael G Kemp; Aziz Sancar
Journal:  J Biol Chem       Date:  2015-10-05       Impact factor: 5.157

6.  Base pair conformation-dependent excision of benzo[a]pyrene diol epoxide-guanine adducts by human nucleotide excision repair enzymes.

Authors:  M T Hess; D Gunz; N Luneva; N E Geacintov; H Naegeli
Journal:  Mol Cell Biol       Date:  1997-12       Impact factor: 4.272

7.  ATR Kinase Inhibition Protects Non-cycling Cells from the Lethal Effects of DNA Damage and Transcription Stress.

Authors:  Michael G Kemp; Aziz Sancar
Journal:  J Biol Chem       Date:  2016-03-03       Impact factor: 5.157

8.  The SWI/SNF chromatin-remodeling factor stimulates repair by human excision nuclease in the mononucleosome core particle.

Authors:  Ryujiro Hara; Aziz Sancar
Journal:  Mol Cell Biol       Date:  2002-10       Impact factor: 4.272

9.  The efficiencies of damage recognition and excision correlate with duplex destabilization induced by acetylaminofluorene adducts in human nucleotide excision repair.

Authors:  Jung-Eun Yeo; Andy Khoo; Adebanke F Fagbemi; Orlando D Schärer
Journal:  Chem Res Toxicol       Date:  2012-10-31       Impact factor: 3.739

10.  In search of a mutational hotspot.

Authors:  Z Hatahet; M Zhou; L J Reha-Krantz; S W Morrical; S S Wallace
Journal:  Proc Natl Acad Sci U S A       Date:  1998-07-21       Impact factor: 11.205
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