| Literature DB >> 7692729 |
A E Wennerberg1, M A Nalesnik, W B Coleman.
Abstract
Hepatocyte paraffin 1 is a monoclonal antibody that has been developed specifically to react with hepatocytes in routine formalin-fixed and paraffin-embedded surgical pathology tissues. It results in a distinct, granular cytoplasmic staining of hepatocytes but fails to react with bile ducts and nonparenchymal liver cells. The antibody decorates a majority of hepatocellular carcinomas, including fibrolamellar variants. It fails to react with a wide variety of other adult malignancies, with the exception of focal staining in a few gastrointestinal malignancies, including a subpopulation of gastric carcinomas.Entities:
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Year: 1993 PMID: 7692729 PMCID: PMC1887067
Source DB: PubMed Journal: Am J Pathol ISSN: 0002-9440 Impact factor: 4.307