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Literature DB >> 768987

Influence of polyunsaturated fatty acids on survival of skin allografts and tumor incidence in mice.

Abstract

Subcutaneous or oral administration of the polyunsaturated fatty acid linoleic acid prolongs survival of skin allografts in mice. Mice fed on a diet deficient in polyunsaturated fatty acids show a relative immunopotentiation, as indicated by accelerated skin allograft rejection and decreased incidence and rate of development of methylcholanthrene-induced tumors. These observations support the hypothesis that polyunsaturated fatty acids take part in immunoregulatory mechanisms.

Entities: Chemical Disease Species

Mesh：

Substances：
Methylcholanthrene

Year: 1976 PMID： 768987 PMCID： PMC336033 DOI： 10.1073/pnas.73.3.928

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

8 in total

1. Letter: Prolongation of skin allografts in rats by treatment with linoleic acid.

Authors: J Ring; J Seifert; J Mertin; W Brendel
Journal: Lancet Date: 1974-11-30 Impact factor: 79.321

2. The effects of a series of prostaglandins on in vitro models of the allergic response and cellular immunity.

Authors: L M Lichtenstein; E Gillespie; H R Bourne; C S Henney
Journal: Prostaglandins Date: 1972-12

3. Immune resistance and malnutrition.

Authors: D G Jose; R A Good
Journal: Lancet Date: 1972-02-05 Impact factor: 79.321

4. In-vitro inhibition by unsaturated fatty acids of the PPD- and PHA-induced lymphocyte response.

Authors: J Mertin; D Hughes; B K Shenton; J P Dickinson
Journal: Klin Wochenschr Date: 1974-03-01

5. Long term effects on immune function of early nutritional deprivation.

Authors: D G Jose; O Stutman; R A Good
Journal: Nature Date: 1973-01-05 Impact factor: 49.962

6. High levels of free fatty acids in lymphoid cells, with special reference to their cytotoxicity.

Authors: S Kigoshi; R Ito
Journal: Experientia Date: 1973-11-15

7. Absence of enhancing antibody in cell mediated immunity to tumour heterografts in protein deficient rats.

Authors: D G Jose; R A Good
Journal: Nature Date: 1971-06-04 Impact factor: 49.962

8. Specific inhibitory action of polyunsaturated fatty acids on lymphocyte transformation induced by PHA and PPD.

Authors: J Mertin; D Hughes
Journal: Int Arch Allergy Appl Immunol Date: 1975

8 in total

13 in total

1. Pharmacological control of the hormonally modulated immune response. II. Blockade of antibody production by a combination of drugs acting on neuroendocrine functions. Its prevention by gonadotropins and corticotrophin.

Authors: W Pierpaoli; G J Maestroni
Journal: Immunology Date: 1978-03 Impact factor: 7.397

Review 2. Nutrition and autoimmunity: a review.

Authors: J Homsy; W J Morrow; J A Levy
Journal: Clin Exp Immunol Date: 1986-09 Impact factor: 4.330

3. Fat overload from 10 percent soybean oil emulsion in a marrow transplant recipient.

Authors: R F Taylor; C D Buckner
Journal: West J Med Date: 1982-04

4. Essential fatty acid deficiency depletes rat glomeruli of resident macrophages and inhibits angiotensin II-induced eicosanoid synthesis.

Authors: J B Lefkowith; G Schreiner
Journal: J Clin Invest Date: 1987-10 Impact factor: 14.808

Influence of polyunsaturated fatty acids on survival of skin allografts and tumor incidence in mice.

1. Letter: Prolongation of skin allografts in rats by treatment with linoleic acid.

2. The effects of a series of prostaglandins on in vitro models of the allergic response and cellular immunity.

3. Immune resistance and malnutrition.

4. In-vitro inhibition by unsaturated fatty acids of the PPD- and PHA-induced lymphocyte response.

5. Long term effects on immune function of early nutritional deprivation.

6. High levels of free fatty acids in lymphoid cells, with special reference to their cytotoxicity.

7. Absence of enhancing antibody in cell mediated immunity to tumour heterografts in protein deficient rats.

8. Specific inhibitory action of polyunsaturated fatty acids on lymphocyte transformation induced by PHA and PPD.

1. Pharmacological control of the hormonally modulated immune response. II. Blockade of antibody production by a combination of drugs acting on neuroendocrine functions. Its prevention by gonadotropins and corticotrophin.

Review 2. Nutrition and autoimmunity: a review.

3. Fat overload from 10 percent soybean oil emulsion in a marrow transplant recipient.

4. Essential fatty acid deficiency depletes rat glomeruli of resident macrophages and inhibits angiotensin II-induced eicosanoid synthesis.

5. The effect of free fatty acids on spectrin organization in lymphocytes.

6. The spleen is required for the suppression of experimental allergic encephalomyelitis by prostaglandin precursors.

7. Dietary fat affects immune response, production of antiviral factors, and immune complex disease in NZB/NZW mice.

Review 8. Effects of fatty acids on gap junctional communication: possible role in tumor promotion by dietary fat.

9. Anti-cancer action of retinoids.

10. Dose response of fish oil versus safflower oil on graft arteriosclerosis in rabbit heterotopic cardiac allografts.