Literature DB >> 7671310

TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.

P W Greenwell1, S L Kronmal, S E Porter, J Gassenhuber, B Obermaier, T D Petes.   

Abstract

Yeast chromosomes terminate in tracts of simple repetitive DNA (poly[G1-3T]). Mutations in the gene TEL1 result in shortened telomeres. Sequence analysis of TEL1 indicates that it encodes a very large (322 kDa) protein with amino acid motifs found in phosphatidylinositol/protein kinases. The closest homolog to TEL1 is the human ataxia telangiectasia gene.

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Year:  1995        PMID： 7671310     DOI： 10.1016/0092-8674(95)90479-4

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  162 in total

1.  Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase.

Authors:  J Xia; Y Peng; I S Mian; N F Lue
Journal:  Mol Cell Biol       Date:  2000-07       Impact factor: 4.272

2.  Global analysis of ATM polymorphism reveals significant functional constraint.

Authors:  Y R Thorstenson; P Shen; V G Tusher; T L Wayne; R W Davis; G Chu; P J Oefner
Journal:  Am J Hum Genet       Date:  2001-07-03       Impact factor: 11.025

3.  Suppression of genome instability by redundant S-phase checkpoint pathways in Saccharomyces cerevisiae.

Authors:  Kyungjae Myung; Richard D Kolodner
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-26       Impact factor: 11.205

Review 4.  Natural and pharmacological regulation of telomerase.

Authors:  Jean-Louis Mergny; Jean-François Riou; Patrick Mailliet; Marie-Paule Teulade-Fichou; Eric Gilson
Journal:  Nucleic Acids Res       Date:  2002-02-15       Impact factor: 16.971

5.  Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathway.

Authors:  V Paciotti; M Clerici; M Scotti; G Lucchini; M P Longhese
Journal:  Mol Cell Biol       Date:  2001-06       Impact factor: 4.272

6.  The yeast TEL1 gene partially substitutes for human ATM in suppressing hyperrecombination, radiation-induced apoptosis and telomere shortening in A-T cells.

Authors:  E Fritz; A A Friedl; R M Zwacka; F Eckardt-Schupp; M S Meyn
Journal:  Mol Biol Cell       Date:  2000-08       Impact factor: 4.138

7.  Isolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype.

Authors:  N Zhang; P Chen; K K Khanna; S Scott; M Gatei; S Kozlov; D Watters; K Spring; T Yen; M F Lavin
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-22       Impact factor: 11.205

8.  Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase.

Authors:  J C Mallory; T D Petes
Journal:  Proc Natl Acad Sci U S A       Date:  2000-12-05       Impact factor: 11.205

9.  The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae.

Authors:  Shivani Nautiyal; Joseph L DeRisi; Elizabeth H Blackburn
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-25       Impact factor: 11.205

10.  A quantitative assay for telomere protection in Saccharomyces cerevisiae.

Authors:  Michelle L DuBois; Zara W Haimberger; Martin W McIntosh; Daniel E Gottschling
Journal:  Genetics       Date:  2002-07       Impact factor: 4.562
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