| Literature DB >> 7670496 |
E I Rugarli1, D A Adler, G Borsani, K Tsuchiya, B Franco, X Hauge, C Disteche, V Chapman, A Ballabio.
Abstract
We report the unprecedented finding of a gene with a different map position in two mouse strains. The Clcn4 gene was found to map to the X chromosome in the wild Mediterrean mouse, Mus spretus but to chromosome 7 in the inbred strain of laboratory mouse C57BL/6J. These data indicate that a recent evolutionary rearrangement occurred on the mouse sex chromosomes, very close to the pseudoautosomal region. Our data provide molecular evidence for a major divergence near the pseudoautosomal region, consistent with the hypothesis that hybrid sterility in these species results from abnormal pairing of sex chromosomes during male meiosis.Entities:
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Year: 1995 PMID： 7670496 DOI： 10.1038/ng0895-466
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330