| Literature DB >> 7668280 |
L B Jorde1, M J Bamshad, W S Watkins, R Zenger, A E Fraley, P A Krakowiak, K D Carpenter, H Soodyall, T Jenkins, A R Rogers.
Abstract
To test hypotheses about the origin of modern humans, we analyzed mtDNA sequences, 30 nuclear restriction-site polymorphisms (RSPs), and 30 tetranucleotide short tandem repeat (STR) polymorphisms in 243 Africans, Asians, and Europeans. An evolutionary tree based on mtDNA displays deep African branches, indicating greater genetic diversity for African populations. This finding, which is consistent with previous mtDNA analyses, has been interpreted as evidence for an African origin of modern humans. Both sets of nuclear polymorphisms, as well as a third set of trinucleotide polymorphisms, are highly consistent with one another but fail to show deep branches for African populations. These results, which represent the first direct comparison of mtDNA and nuclear genetic data in major continental populations, undermine the genetic evidence for an African origin of modern humans.Entities:
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Year: 1995 PMID： 7668280 PMCID： PMC1801280 DOI： 10.1002/ajmg.1320570340
Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025