PURPOSE: To evaluate the histologic and angiographic effects of collagen microbeads as an embolic agent in the swine rete mirabile. METHODS: Human collagen particles (380 +/- 100 microns) of spheroidal shape and smooth surface were used to embolize the rete mirabile in five swine. Control angiograms and pathologic examinations were obtained immediately and sequentially from 3 to 35 days after embolization. RESULTS: The collagen particles were easy to inject through microcatheters. Embolization was always angiographically complete and persistent for at least 5 weeks. Histologic studies showed occlusion of 25% to 50% of the rete vessels. After 3 and 5 weeks' follow-up, transmural and adventitial chronic inflammation was present. Inflammatory infiltrates included lymphohistiocytic cells and scattered eosinophils. The foreign-body giant-cell reaction was pronounced. No evidence of angionecrosis or focal hemorrhage was shown. CONCLUSIONS: Collagen microbeads are a promising experimental embolic agent, with potential future applications in humans.
PURPOSE: To evaluate the histologic and angiographic effects of collagen microbeads as an embolic agent in the swine rete mirabile. METHODS:Human collagen particles (380 +/- 100 microns) of spheroidal shape and smooth surface were used to embolize the rete mirabile in five swine. Control angiograms and pathologic examinations were obtained immediately and sequentially from 3 to 35 days after embolization. RESULTS: The collagen particles were easy to inject through microcatheters. Embolization was always angiographically complete and persistent for at least 5 weeks. Histologic studies showed occlusion of 25% to 50% of the rete vessels. After 3 and 5 weeks' follow-up, transmural and adventitial chronic inflammation was present. Inflammatory infiltrates included lymphohistiocytic cells and scattered eosinophils. The foreign-body giant-cell reaction was pronounced. No evidence of angionecrosis or focal hemorrhage was shown. CONCLUSIONS: Collagen microbeads are a promising experimental embolic agent, with potential future applications in humans.
Authors: Y Kai; J-I Hamada; M Morioka; S Yano; H Nakamura; K Makino; T Mizuno; H Takeshima; J-I Kuratsu Journal: AJNR Am J Neuroradiol Date: 2006-05 Impact factor: 3.825
Authors: Todd Abruzzo; Harry J Cloft; Miroslav Marek; George G Shengelaia; Patrick B Snowhill; Sandra Miller Waldrop; Athanassios Sambanis Journal: AJNR Am J Neuroradiol Date: 2002-04 Impact factor: 3.825
Authors: Marc Melià-Sorolla; Carlos Castaño; Núria DeGregorio-Rocasolano; Luis Rodríguez-Esparragoza; Antoni Dávalos; Octavi Martí-Sistac; Teresa Gasull Journal: Int J Mol Sci Date: 2020-09-08 Impact factor: 5.923