BACKGROUND AND PURPOSE: Our newly developed biocompatible embolic materials, hydroxyapatite ceramic microparticles, have good visibility during injection control and were shown to be capable of producing effective occlusion of the distal arteriocapillary bed in an experimental animal study. The purpose of this present study was to evaluate hydroxyapatite ceramic microparticles for use in human meningioma embolization. METHODS: Thirteen patients with meningiomas underwent preoperative superselective embolization with the use of hydroxyapatite microparticles. Radiologic and histopathologic studies of the surgical specimens were performed. RESULTS: During embolization, no microcatheter clogging was observed and angiographic devascularization was consistently obtained without unexpected proximal occlusions. Histopathologic findings showed that there was mild inflammatory response in the thrombosed lumen. CONCLUSION: Hydroxyapatite microparticles are excellent embolic materials for the treatment of human meningioma. They have excellent biocompatibility and good injection control, which produces occlusion of the distal arteriocapillary bed.
BACKGROUND AND PURPOSE: Our newly developed biocompatible embolic materials, hydroxyapatite ceramic microparticles, have good visibility during injection control and were shown to be capable of producing effective occlusion of the distal arteriocapillary bed in an experimental animal study. The purpose of this present study was to evaluate hydroxyapatite ceramic microparticles for use in humanmeningioma embolization. METHODS: Thirteen patients with meningiomas underwent preoperative superselective embolization with the use of hydroxyapatite microparticles. Radiologic and histopathologic studies of the surgical specimens were performed. RESULTS: During embolization, no microcatheter clogging was observed and angiographic devascularization was consistently obtained without unexpected proximal occlusions. Histopathologic findings showed that there was mild inflammatory response in the thrombosed lumen. CONCLUSION:Hydroxyapatite microparticles are excellent embolic materials for the treatment of humanmeningioma. They have excellent biocompatibility and good injection control, which produces occlusion of the distal arteriocapillary bed.
Authors: J S Schweitzer; B S Chang; P Madsen; F Viñuela; N A Martin; C E Marroquin; H V Vinters Journal: Neuroradiology Date: 1993 Impact factor: 2.804
Authors: A K Wakhloo; F D Juengling; V Van Velthoven; M Schumacher; J Hennig; K Schwechheimer Journal: AJNR Am J Neuroradiol Date: 1993 May-Jun Impact factor: 3.825
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Authors: Y Kai; J-I Hamada; M Morioka; S Yano; H Nakamura; K Makino; T Mizuno; H Takeshima; J-I Kuratsu Journal: AJNR Am J Neuroradiol Date: 2006-05 Impact factor: 3.825