PURPOSE: To correlate histopathologic and magnetic resonance (MR) imaging findings of ductal carcinoma in situ (DCIS). MATERIALS AND METHODS: Thirty-six women with DCIS underwent preoperative contrast material-enhanced subtraction dynamic MR imaging. Concomitant early contrast enhancement in the breast parenchyma with normal vessels was considered a positive finding. The size and shape of early enhancement were correlated with the size and density packing of ducts involved by DCIS. Tumor angiogenesis in the stroma that surrounded the ducts was evaluated with immunoperoxidase staining. RESULTS: Early contrast enhancement was demonstrated in 34 patients with DCIS but not in two patients with comedo-type DCIS. Tumor angiogenesis was demonstrated in the stroma. The size and morphology of contrast-enhanced lesions significantly correlated with the size (P = .0085) and density packing of ducts involved by DCIS (P = .012). CONCLUSION: Contrast enhancement on dynamic MR images of DCIS may be due to the presence of tumor angiogenesis in the stroma.
PURPOSE: To correlate histopathologic and magnetic resonance (MR) imaging findings of ductal carcinoma in situ (DCIS). MATERIALS AND METHODS: Thirty-six women with DCIS underwent preoperative contrast material-enhanced subtraction dynamic MR imaging. Concomitant early contrast enhancement in the breast parenchyma with normal vessels was considered a positive finding. The size and shape of early enhancement were correlated with the size and density packing of ducts involved by DCIS. Tumor angiogenesis in the stroma that surrounded the ducts was evaluated with immunoperoxidase staining. RESULTS: Early contrast enhancement was demonstrated in 34 patients with DCIS but not in two patients with comedo-type DCIS. Tumor angiogenesis was demonstrated in the stroma. The size and morphology of contrast-enhanced lesions significantly correlated with the size (P = .0085) and density packing of ducts involved by DCIS (P = .012). CONCLUSION: Contrast enhancement on dynamic MR images of DCIS may be due to the presence of tumor angiogenesis in the stroma.
Authors: Tibor Vag; Pascal A T Baltzer; Matthias Dietzel; Ramy Zoubi; Mieczyslaw Gajda; Oumar Camara; Werner A Kaiser Journal: Eur Radiol Date: 2010-11-10 Impact factor: 5.315
Authors: Sanaz A Jansen; Xiaobing Fan; Gregory S Karczmar; Hiroyuki Abe; Robert A Schmidt; Maryellen Giger; Gillian M Newstead Journal: Med Phys Date: 2008-07 Impact factor: 4.071
Authors: F Sardanelli; L Bacigalupo; L Carbonaro; A Esseridou; G M Giuseppetti; P Panizza; V Lattanzio; A Del Maschio Journal: Radiol Med Date: 2008-07-09 Impact factor: 3.469
Authors: Julio Cárdenas-Rodríguez; Christine M Howison; Terry O Matsunaga; Mark D Pagel Journal: Magn Reson Imaging Date: 2013-04-11 Impact factor: 2.546