OBJECTIVE: To analyse the kinetic characteristics of lesions without mass effect in dynamic breast MRI using manual and computer assisted methods. METHODS: The enhancement pattern of 82 histopathologically verified lesions without mass effect (36 malignant, 46 benign) was evaluated on breast MRI using manual placement of a region of interest. Commercially available computer analysis software automatically assessed volume enhancement characteristics of a lesion voxelwise. Kinetic features evaluated included classification of the signal-intensity time curve as washout, plateau or persistent enhancement. RESULTS: Unlike manual ROI placement, computer-aided analysis demonstrated a significant difference in enhancement pattern between benign (washout: 32.6%, plateau: 32.6%, persistent: 34.8%) and malignant lesions without mass effect (77.1%, 8.6%, 14.3% respectively, P < 0.01, two-sided Chi-squared test) following initial rapid signal increase. Mean percentage of washout voxel volumes within a lesion was significantly higher in malignant lesions than in benign lesions (11.9% +/-12.7 (SD) vs. 6.9% +/-11.3 (SD), P < 0.01, Mann-Whitney U Test). Conversely, the mean percentage of persistent voxel volumes was significantly lower in malignant lesions than in benign lesions (60.1% +/-21.1 (SD) vs. 79% +/-23 (SD), P < 0.01, Mann-Whitney U Test). CONCLUSION: Computer-assisted enhancement pattern analysis might have diagnostic benefit in the evaluation of lesions without mass effect.
OBJECTIVE: To analyse the kinetic characteristics of lesions without mass effect in dynamic breast MRI using manual and computer assisted methods. METHODS: The enhancement pattern of 82 histopathologically verified lesions without mass effect (36 malignant, 46 benign) was evaluated on breast MRI using manual placement of a region of interest. Commercially available computer analysis software automatically assessed volume enhancement characteristics of a lesion voxelwise. Kinetic features evaluated included classification of the signal-intensity time curve as washout, plateau or persistent enhancement. RESULTS: Unlike manual ROI placement, computer-aided analysis demonstrated a significant difference in enhancement pattern between benign (washout: 32.6%, plateau: 32.6%, persistent: 34.8%) and malignant lesions without mass effect (77.1%, 8.6%, 14.3% respectively, P < 0.01, two-sided Chi-squared test) following initial rapid signal increase. Mean percentage of washout voxel volumes within a lesion was significantly higher in malignant lesions than in benign lesions (11.9% +/-12.7 (SD) vs. 6.9% +/-11.3 (SD), P < 0.01, Mann-Whitney U Test). Conversely, the mean percentage of persistent voxel volumes was significantly lower in malignant lesions than in benign lesions (60.1% +/-21.1 (SD) vs. 79% +/-23 (SD), P < 0.01, Mann-Whitney U Test). CONCLUSION: Computer-assisted enhancement pattern analysis might have diagnostic benefit in the evaluation of lesions without mass effect.
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