AIMS: To propose a computerised image analysis based method for measuring, on paper mounted lung sections, the area macroscopically occupied by emphysema. METHODS: The study was based on the assessment of 69 lung sections prepared following a modified Gough-Wentworth technique. The results obtained from image analysis, point counting, and panel grading methods were compared, as was the repeatability of image analysis and panel grading. RESULTS: The results from image analysis and from point counting were not significantly different (p = 0.609) and significant quadratic regressions (r = 0.96, p < 0.001) were found between measurements from image analysis and from panel grading, the computerised technique being shown to be the most reproducible. CONCLUSIONS: Image analysis is a valuable and reproducible method to measure the area of lung macroscopically involved by emphysema.
AIMS: To propose a computerised image analysis based method for measuring, on paper mounted lung sections, the area macroscopically occupied by emphysema. METHODS: The study was based on the assessment of 69 lung sections prepared following a modified Gough-Wentworth technique. The results obtained from image analysis, point counting, and panel grading methods were compared, as was the repeatability of image analysis and panel grading. RESULTS: The results from image analysis and from point counting were not significantly different (p = 0.609) and significant quadratic regressions (r = 0.96, p < 0.001) were found between measurements from image analysis and from panel grading, the computerised technique being shown to be the most reproducible. CONCLUSIONS: Image analysis is a valuable and reproducible method to measure the area of lung macroscopically involved by emphysema.
Authors: Miranda Kirby; Charles Hatt; Nancy Obuchowski; Stephen M Humphries; Jered Sieren; David A Lynch; Sean B Fain Journal: Med Phys Date: 2020-03-31 Impact factor: 4.071
Authors: Elizabeth C Oelsner; Victor E Ortega; Benjamin M Smith; Jennifer N Nguyen; Ani W Manichaikul; Eric A Hoffman; Xiuqing Guo; Kent D Taylor; Prescott G Woodruff; David J Couper; Nadia N Hansel; Fernando J Martinez; Robert Paine; Meilan K Han; Christopher Cooper; Mark T Dransfield; Gerard Criner; Jerry A Krishnan; Russell Bowler; Eugene R Bleecker; Stephen Peters; Stephen S Rich; Deborah A Meyers; Jerome I Rotter; R Graham Barr Journal: Am J Respir Crit Care Med Date: 2019-09-15 Impact factor: 21.405