J Liu1, Y Liu, C D Klaassen. 1. Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66160-7417, USA.
Abstract
AIM: To evaluate the protective effect of oleanolic acid (OA) against necrotic liver injury. METHODS: Mice were pretreated with OA (200 mumol.kg-1, sc for 3 d), and subsequently administered hepatotoxicants. Liver damage was assessed by quantifying serum activities of alanine aminotransferase and iditol (sorbitol) dehydrogenase, as well as by histopathological examination. RESULTS: OA pretreatment dramatically diminished CCl4-, bromobenzene-, acetaminophen-, phalloidin-, and cadmium-induced liver injury, and decreased the hepatotoxicity of D-galactosamine plus endotoxin, thioacetamide, furosemide, and colchicine. However, OA had no effect on the toxicity of dimethylnitrosamine, alpha-amanitin, chloroform, and allyl alcohol. CONCLUSION: OA protects against many, but not all, hepatotoxicants, and the hepatoprotective effect of OA may involve multiple mechanisms.
AIM: To evaluate the protective effect of oleanolic acid (OA) against necrotic liver injury. METHODS:Mice were pretreated with OA (200 mumol.kg-1, sc for 3 d), and subsequently administered hepatotoxicants. Liver damage was assessed by quantifying serum activities of alanine aminotransferase and iditol (sorbitol) dehydrogenase, as well as by histopathological examination. RESULTS:OA pretreatment dramatically diminished CCl4-, bromobenzene-, acetaminophen-, phalloidin-, and cadmium-induced liver injury, and decreased the hepatotoxicity of D-galactosamine plus endotoxin, thioacetamide, furosemide, and colchicine. However, OA had no effect on the toxicity of dimethylnitrosamine, alpha-amanitin, chloroform, and allyl alcohol. CONCLUSION:OA protects against many, but not all, hepatotoxicants, and the hepatoprotective effect of OA may involve multiple mechanisms.
Authors: Jules C N Assob; Henri L F Kamga; Dickson S Nsagha; Anna L Njunda; Peter F Nde; Emmanuel A Asongalem; Abdel J Njouendou; Bertrand Sandjon; Veronique B Penlap Journal: BMC Complement Altern Med Date: 2011-08-25 Impact factor: 3.659