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Literature DB >> 759556

The matrix protein gene determines amantadine-sensitivity of influenza viruses.

A J Hay, N C Kennedy, J J Skehel, G Appleyard.

Abstract

The genetic composition of several recombinant strains, produced by mixed infection with an amantadine-sensitive and an amantadine-resistant influenza virus, have been compared with their response to amantadine. It is concluded that transfer of resistance or sensitivity to amantadine is determined by a single gene, that coding for the matrix protein.

Entities: Chemical Species

Mesh：

Substances：
Viral Proteins
Amantadine

Year: 1979 PMID： 759556 DOI： 10.1099/0022-1317-42-1-189

Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891

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Cited

17 in total

1. Growth restriction of influenza A virus by M2 protein antibody is genetically linked to the M1 protein.

Authors: S L Zebedee; R A Lamb
Journal: Proc Natl Acad Sci U S A Date: 1989-02 Impact factor: 11.205

2. Influenza virus strains with a fusion threshold of pH 5.5 or lower are inhibited by amantadine. Brief report.

Authors: W E Beyer; R W Ruigrok; H van Driel; N Masurel
Journal: Arch Virol Date: 1986 Impact factor: 2.574

3. Genetic basis of resistance to rimantadine emerging during treatment of influenza virus infection.

Authors: R B Belshe; M H Smith; C B Hall; R Betts; A J Hay
Journal: J Virol Date: 1988-05 Impact factor: 5.103

Review 4. The entry of enveloped viruses into cells by endocytosis.

Authors: M Marsh
Journal: Biochem J Date: 1984-02-15 Impact factor: 3.857

5. Influence of membrane (M) protein on influenza A virus virion transcriptase activity in vitro and its susceptibility to rimantadine.

Authors: A Y Zvonarjev; Y Z Ghendon
Journal: J Virol Date: 1980-02 Impact factor: 5.103

The matrix protein gene determines amantadine-sensitivity of influenza viruses.

1. Growth restriction of influenza A virus by M2 protein antibody is genetically linked to the M1 protein.

2. Influenza virus strains with a fusion threshold of pH 5.5 or lower are inhibited by amantadine. Brief report.

3. Genetic basis of resistance to rimantadine emerging during treatment of influenza virus infection.

Review 4. The entry of enveloped viruses into cells by endocytosis.

5. Influence of membrane (M) protein on influenza A virus virion transcriptase activity in vitro and its susceptibility to rimantadine.

6. Rimantadine hydrochloride blocks the second step of influenza virus uncoating.

7. The amantadine-sensitivity of recombinant and parental influenza virus strains.

8. Structure and dynamics of the influenza A M2 channel: a comparison of three structures.

9. pH-driven helix rotations in the influenza M2 H+ channel: a potential gating mechanism.

10. Characterization of the 1918 "Spanish" influenza virus matrix gene segment.